血液透析对终末期肾病患儿整体和局部心脏功能的影响。
Effect of Hemodialysis on Global and Regional Cardiac Function in Children With End-stage Renal Disease.
作者信息
Amoozgar Hamid, Naghshzan Amir, Basiratnia Mitra, Ahmadipoor Maryam
机构信息
Department of Pediatrics; Department of Pediatric Cardiology, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
出版信息
Iran J Kidney Dis. 2018 Jan;12(1):48-52.
INTRODUCTION
Changes in cardiac structure and function are common among patients with end-stage renal disease. The aim of this study was to evaluate the effect of hemodialysis on global and segmental cardiac function in children with end-stage renal disease.
MATERIALS AND METHODS
Fifty-two children with ESRD who were on long-term hemodialysis at Nemazee Hospital, Shiraz, were enrolled. They underwent echocardiography (M-mode, 2-dimensional, Doppler, and speckle echocardiography) 30 minutes prior to and after hemodialysis, and the values were compared.
RESULTS
The mean age of the patients was 13.00 ± 3.53 years. There was a significant reduction in left ventricular systolic and diastolic dimensions and volume (P < .001) and the E:A ratio after dialysis (P = .03). Global and longitudinal strain and strain rate showed no significant changes before and after hemodialysis.
CONCLUSIONS
Hemodialysis with volume reduction decreases left ventricular volume but not regional strain and strain rate significantly in children. This study showed preload independency of speckle echocardiography in children.
引言
心脏结构和功能的改变在终末期肾病患者中很常见。本研究的目的是评估血液透析对终末期肾病儿童整体和节段性心脏功能的影响。
材料与方法
纳入了设拉子内马齐医院52例接受长期血液透析的终末期肾病儿童。他们在血液透析前30分钟和后接受了超声心动图检查（M型、二维、多普勒和斑点超声心动图），并对数值进行了比较。
结果
患者的平均年龄为13.00±3.53岁。透析后左心室收缩和舒张维度及容积显著减小（P<.001），E:A比值降低（P=.03）。整体和纵向应变及应变率在血液透析前后无显著变化。
结论
减少容量的血液透析可降低儿童左心室容积，但对区域应变和应变率无显著影响。本研究表明斑点超声心动图在儿童中具有前负荷独立性。
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