Tibboel D, Vermey-Keers C, Klück P, Gaillard J L, Koppenberg J, Molenaar J C
Teratology. 1986 Jun;33(3):267-72. doi: 10.1002/tera.1420330303.
Patients with gastroschisis have a paraumbilical defect of the anterior abdominal wall through which bowel loops protrude. These bowel loops are edematous and covered by a fibrous coating. The moment of occurrence of gastroschisis as well as the development of the fibrous coating are unknown. This prompted an investigation of 26 human embryos and fetuses with gastroschisis at various developmental stages (crown-rump length 25-240 mm) and two stillborn fetuses (gestational age 30 weeks) with gastroschisis, as well as resected material from ten newborns (gestational age 33-40 weeks) operated for gastroschisis. Progressive changes of the serosa were only noted after the 30th week of gestation and consisted of an amniotic fluid peritonitis and progressive fibrosis. The changes are in agreement with experimental data and correlate with changes in the composition of amniotic fluid. The findings prove that gastroschisis is a very early occurrence, while the fibrous coating is a late development.
腹裂患者前腹壁存在脐旁缺损，肠袢由此突出。这些肠袢水肿，被一层纤维膜覆盖。腹裂的发生时间以及纤维膜的形成过程尚不清楚。这促使研究人员对26例处于不同发育阶段（顶臀长25 - 240毫米）的腹裂人类胚胎和胎儿、2例30周胎龄的腹裂死产胎儿以及10例因腹裂接受手术的33 - 40周胎龄新生儿的切除组织进行研究。仅在妊娠30周后才观察到浆膜的渐进性变化，包括羊水腹膜炎和进行性纤维化。这些变化与实验数据一致，并与羊水成分的变化相关。研究结果证明腹裂是很早就发生的，而纤维膜是晚期形成的。
