使用可诱导胆固醇流出（iCE）肽FAMP提高心肌梗死后的存活率。
Improved survival rate after myocardial infarction using an inducible cholesterol efflux (iCE) peptide: FAMP.
作者信息
Yahiro Eiji, Uehara Yoshinari, Kawachi Emi, Ando Setsuko, Miura Shin-Ichiro, Saku Keijiro
机构信息
Department of Cardiology, Fukuoka University School of Medicine, Japan.
The AIG Collaborative Research Institute of Cardiovascular Medicine, Japan.
出版信息
Int J Cardiol Heart Vessel. 2014 May 25;4:135-137. doi: 10.1016/j.ijchv.2014.05.005. eCollection 2014 Sep.
BACKGROUND
There have been no previous reports that apolipoprotein (apo) A-I mimetic peptide improves survival rate after myocardial infarction (MI).
METHOD AND RESULTS
Male C57Bl/6J mice were subjected to left coronary artery permanent ligation as a model of MI. We synthesized a novel 24-amino acid apoA-I mimetic peptide-type5 (FAMP5), which potently removes cholesterol via specific ATP-binding cassette transporter A1 (ABCA1). FAMP5 was associated with a significantly improved survival rate by protecting against cardiac rupture compared to the control. mRNA levels for eNOS, Gata-4, CTGF and ANP were significantly increased in the hearts of the FAMP5-treated group, while that for MCP-1 decreased.
CONCLUSION
This is the first report that high-density lipoprotein (HDL) therapy with FAMP5 improved the survival rate after MI.
背景
此前尚无载脂蛋白（apo）A-I模拟肽可提高心肌梗死（MI）后生存率的报道。
方法与结果
将雄性C57Bl/6J小鼠进行左冠状动脉永久性结扎作为MI模型。我们合成了一种新型的24个氨基酸的apoA-I模拟肽5型（FAMP5），它可通过特异性ATP结合盒转运体A1（ABCA1）有效清除胆固醇。与对照组相比，FAMP5通过预防心脏破裂显著提高了生存率。FAMP5治疗组心脏中eNOS、Gata-4、CTGF和ANP的mRNA水平显著升高，而MCP-1的mRNA水平降低。
结论
这是首次报道FAMP5进行高密度脂蛋白（HDL）治疗可提高MI后的生存率。
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