Gol'zand I V, Murav'eva N N, Goriacheva L G
Zh Mikrobiol Epidemiol Immunobiol. 1986 Aug(8):38-41.
The work deals with the results of the study of T-lymphocytes and their subpopulations (active, thermostable, theophylline-sensitive and theophylline-resistant) in 102 children with chronic viral hepatitis B, depending on the effectiveness of thymalin therapy. The sensitization of lymphocytes to specific antigens was studied. Among patients with chronic viral hepatitis B and cirrhosis of the liver the homozygous phenotype of haptoglobin is registered essentially more frequently (63.6% and 82.4% respectively) than among healthy persons (44.0%). The patients of this group showed a decrease in the number of T-lymphocytes, disturbances in the suppressor/helper ratio: hypersuppression in persisting hepatitis and hyposuppression in active hepatitis. In 71.6% of cases thymalin therapy produced an effect manifested by clinico-biochemical remission, an increase in the number of T-lymphocytes, thermostable cells and the normalization of the T-suppressor/T-helper ratio. In these patients sensitization to HBsAg essentially decreased (from 30.5% to 13.9%), while sensitization to human liver lipoprotein retained its high level even after treatment with thymalin.
这项研究针对102例慢性乙型病毒性肝炎患儿，根据胸腺素治疗效果，对T淋巴细胞及其亚群（活性、耐热、对茶碱敏感和对茶碱耐药的亚群）进行了研究。研究了淋巴细胞对特定抗原的致敏作用。在慢性乙型病毒性肝炎和肝硬化患者中，触珠蛋白的纯合子表型出现的频率（分别为63.6%和82.4%）显著高于健康人（44.0%）。该组患者的T淋巴细胞数量减少，抑制/辅助比例失调：持续性肝炎中出现超抑制，活动性肝炎中出现低抑制。在71.6%的病例中，胸腺素治疗产生了效果，表现为临床生化缓解、T淋巴细胞数量增加、耐热细胞数量增加以及T抑制细胞/T辅助细胞比例正常化。在这些患者中，对乙肝表面抗原的致敏作用显著降低（从30.5%降至13.9%），而即使在接受胸腺素治疗后，对人肝脂蛋白的致敏作用仍保持在较高水平。
