Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China; Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, China; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China; Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong, China; Department of Microbiology, Queen Mary Hospital, Hong Kong, China.
Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
J Infect. 2018 May;76(5):465-474. doi: 10.1016/j.jinf.2018.02.005. Epub 2018 Feb 15.
We assessed the immunological response of hospitalized adult patients with rhinovirus infection, including critically-ill patients.
The differential white blood cell (WBC) count and the levels of 29 plasma cytokines/chemokines were compared between 50 adult hospitalized patients with rhinovirus infection and 100 age-matched controls with influenza virus infection.
The demographics and comorbidities were similar between rhinovirus and influenza patients, but severe disease was more common for the rhinovirus cohort. Rhinovirus patients had significantly higher WBC counts than influenza patients, especially for eosinophil (P = 3.1 × 10). The level of the T2 cytokine IL-5 was significantly higher among rhinovirus patients, while the levels of 9 other cytokines/chemokines were significantly lower among rhinovirus patients. The levels of CXCL-10 (IP-10), CCL-2 (MCP-1), IFN-α2, IFN-γ, IL-10, and IL-15 remained significantly lower among rhinovirus patients after correction for multiple comparisons. Notably, CXCL-10 had the highest area under the receiver operating characteristic curve (AUC) in differentiating rhinovirus from influenza patients (AUC, 0.918). In the patient subgroup without asthma, the difference in the WBC count and cytokine/chemokine levels between rhinovirus and influenza patients remained statistically significant.
Rhinovirus infection was characterized by a prominent T2 response, even in patients without asthma. CXCL-10 (IP-10) is a potential biomarker in differentiating rhinovirus from influenza infection.
我们评估了住院成人病毒感染患者（包括危重症患者）的免疫反应，包括病毒感染患者。
比较了 50 例住院成人病毒感染患者和 100 例年龄匹配的流感病毒感染患者的白细胞（WBC）差异计数和 29 种血浆细胞因子/趋化因子水平。
病毒和流感患者的人口统计学和合并症相似，但病毒组严重疾病更为常见。病毒感染患者的 WBC 计数明显高于流感患者，尤其是嗜酸性粒细胞（P=3.1×10）。病毒感染患者的 T2 细胞因子 IL-5 水平明显较高，而病毒感染患者的 9 种其他细胞因子/趋化因子水平明显较低。经多次比较校正后，病毒感染患者的 CXCL-10（IP-10）、CCL-2（MCP-1）、IFN-α2、IFN-γ、IL-10 和 IL-15 水平仍明显较低。值得注意的是，CXCL-10 在区分病毒和流感患者方面具有最高的接收者操作特征曲线（AUC）（AUC，0.918）。在无哮喘的患者亚组中，病毒和流感患者之间的 WBC 计数和细胞因子/趋化因子水平差异仍具有统计学意义。
病毒感染的特征是明显的 T2 反应，即使在没有哮喘的患者中也是如此。CXCL-10（IP-10）是区分病毒和流感感染的潜在生物标志物。
