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Assessment of prevalence and clinical outcome of frailty in an elderly predialysis cohort using simple tools.

作者信息

Ali Hatem, Abdelaziz Tarek, Abdelaal Fatima, Baharani Jyoti

机构信息

Department of Renal Medicine, Heart of England Teaching Hospitals NHS Foundation Trust, Birmingham, UK.

出版信息

Saudi J Kidney Dis Transpl. 2018 Jan-Feb;29(1):63-70. doi: 10.4103/1319-2442.225175.


DOI:10.4103/1319-2442.225175
PMID:29456209
Abstract

The relationship between frailty and chronic kidney disease in elderly population has been recognized; however, studies concentrating on frailty in predialysis patients are limited. For nephrologists, the recognition of frailty is important as it has impact on decisions on the choice of dialysis modality and sometimes on whether dialysis is indeed in the patients' best interests. Many of the tools for routine assessment of frailty are not easily applicable to those clinicians not practicing elderly care medicine. A tool needs to be simple and applicable for daily routine practice. The aim of this study was to assess the prevalence and clinical outcome of frailty in an elderly predialysis population using simple tools. A nonrandomized prospective study was conducted in which, 104 patients aged 65 years or above with an estimated glomerular filtration rate of 25 mL or less were included. Data including age, sex, renal function, calcium, albumin, parathormone, and comorbidities were collected at baseline and at three months interval for one year. Functional performance was assessed using Karnofsky scale. The Charlson comorbidity index was used to assess comorbid status of each patient. Frailty was assessed using a combination of PRISMA questionnaire and Timed up and Go test. End points were death or start of dialysis at 20-month follow-up. A frail group (n = 58; males = 32, females = 26) and a nonfrail group (n = 46; males = 21, females = 25) were identified. Frailty was prevalent in 53.8% of the selected population. There was no significant difference between both groups in terms of age, gender, comorbidities, hemoglobin, inflammatory markers, or calcium hemostasis. Nine patients chose conservative management in the frail group and six in nonfrail group. Rate of death was significantly higher in the frail group (death = 14) compared to nonfrail group (death = 3; P = 0.01). There was no significant difference between both groups in terms of initiation of dialysis (P = 0.1). Frailty and Charlson comorbidity index were significantly associated with mortality (P = 0.023 and 0.032, respectively). Survival in frail patients who started peritoneal dialysis (PD) was slightly better than those started on hemodialysis (HD) with hazard ratio = 3.23 (P = 0.23). Our study shows that the prevalence of frailty and mortality rate is high among elderly predialysis patients. Frailty and Charlson comorbidity index are independent predictors of outcome in this population. PD might be a better option of dialysis modality compared to HD in the frail population.

摘要

相似文献

[1]
Assessment of prevalence and clinical outcome of frailty in an elderly predialysis cohort using simple tools.

Saudi J Kidney Dis Transpl. 2018

[2]
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[3]
Assessment of frailty in elderly pre-dialysis population using simple tools.

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[4]
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[8]
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引用本文的文献

[1]
Prospective Study of the Association Between Frailty and Health Care Utilization in Patients With Advanced CKD.

Kidney Int Rep. 2025-3-27

[2]
Frailty Assessment Tools in Chronic Kidney Disease: A Systematic Review and Meta-analysis.

Kidney Med. 2025-1-4

[3]
Usefulness of the Clinical Frailty Scale in patients with end-stage kidney disease.

Clin Kidney J. 2024-5-2

[4]
Frailty in Kidney Disease: A Comprehensive Review to Advance Its Clinical and Research Applications.

Am J Kidney Dis. 2025-1

[5]
Narrative Review: Clinical Implications and Assessment of Frailty in Patients With Advanced CKD.

Kidney Int Rep. 2023-12-30

[6]
The prevalence and influencing factors of frailty in patients with chronic kidney disease: a systematic review and meta-analysis.

Int Urol Nephrol. 2024-2

[7]
Use of frailty assessment instruments in nephrology populations: a scoping review.

BMC Geriatr. 2023-7-21

[8]
Prevalence and Associates of Frailty Status in Different Stages of Chronic Kidney Disease: A Cross-Sectional Study.

J Nutr Health Aging. 2022

[9]
Limitations of the Karnofsky Performance Status Scale in kidney transplant recipients.

Ann Med. 2022-12

[10]
Pre-Frailty and Frailty in Dialysis and Pre-Dialysis Patients: A Systematic Review of Clinical and Biochemical Markers.

Int J Environ Res Public Health. 2021-9-11

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