De Flammineis Eduardo, Mulvaney Patrick M, Kraft Stefan, Mihm Martin C, Das Shinjita, Kroshinsky Daniela
Department of Dermatology, San Raffaele Hospital, Milan, Italy.
Harvard Combined Dermatology Residency Program, Massachusetts General Hospital, Boston, MA, USA.
Dermatopathology (Basel). 2017 Nov 16;4(1-4):18-23. doi: 10.1159/000481727. eCollection 2017 Jan-Dec.
Calciphylaxis is most commonly encountered in patients with end-stage renal disease; however, it is increasingly observed in nonuremic patients as well. It is important to consider and diagnose nonuremic calciphylaxis early, as prompt treatment and mitigation of associated risk factors is essential to improve long-term outcomes for these patients. Here, we present the case of a 71-year-old woman with atrial fibrillation on warfarin, but without renal disease, who presented with two long-standing ulcers on her thigh and was diagnosed with the aid of biopsy with calciphylaxis. We review the existing literature on the subject and offer this case as a representative report of a clinicopathologic correlation for this disorder.
钙过敏症最常见于终末期肾病患者;然而,在非尿毒症患者中也越来越多地观察到。早期考虑并诊断非尿毒症性钙过敏症很重要,因为及时治疗和减轻相关风险因素对于改善这些患者的长期预后至关重要。在此,我们报告一例71岁患有心房颤动且正在服用华法林但无肾病的女性病例,该患者大腿出现两个长期不愈的溃疡,经活检诊断为钙过敏症。我们回顾了关于该主题的现有文献,并提供此病例作为该疾病临床病理相关性的代表性报告。