Mohsen Dehghani Seyed, Ostovar Sedighe, Ataollahi Maryam, Javaherizadeh Hazhir
Gastroenterohepatology Research Center, Shiraz University of Medical Sciences. Shiraz, Iran.
Nursing Care Research Center in Chronic Diseases, Ahvaz Jundishapur University of Medical Sciences. Ahvaz, Iran; Research Center for Infectious Diseases of Digestive System, Ahvaz Jundishapur University of Medical Sciences. Ahvaz, Iran.
Rev Gastroenterol Peru. 2017 Oct-Dec;37(4):323-328.
Celiac disease (CD) is increasingly diagnosed and weight changes are common after adoption of a glutenfree diet (GFD) and there is concern that patients might gain further weight on a GFD.
This study examined to evaluate the impact of a GFD on the body mass index (BMI), whether favorable or unfavorable.
In this retrospective study, we reviewed electronic records of 44 patients with serologic study and intestinal biopsy confirmed CD who was visited in Nemazee hospital, Shiraz. All patients were put on GFD for 2 years and followed closely by pediatric gastroenterologist. BMIs were categories to four group underweight, normal weight, overweight and obese. Initial BMI and follow-up BMI was comparing together and also compared with general population.
At diagnosis, 27.27% of subjects were underweight, 63.64% normal and 9.09% were obese. On a GFD, 66.66% of underweight patients gained weight and became normal weight and 25% of normal weight and 75% of obese patients had increase weight; and the rest of the patients, BMI remained stable. The follow-up BMIs were statistically higher than initial BMIs (mean 17.17 vs. 15.62, p <0.0001).
Individuals with celiac disease have lower BMI than the regional population at diagnosis. On the GFD, BMI is increased significantly in all categories.
乳糜泻（CD）的诊断越来越多，采用无麸质饮食（GFD）后体重变化很常见，人们担心患者在GFD饮食下体重可能会进一步增加。
本研究旨在评估GFD对体重指数（BMI）的影响，无论其是有利还是不利。
在这项回顾性研究中，我们查阅了设拉子内马齐医院44例经血清学研究和肠道活检确诊为CD患者的电子记录。所有患者均采用GFD饮食2年，并由儿科胃肠病学家密切随访。BMI分为体重过轻、正常体重、超重和肥胖四组。将初始BMI与随访BMI进行比较，并与一般人群进行比较。
诊断时，27.27%的受试者体重过轻，63.64%正常，9.09%肥胖。在GFD饮食下，66.66%体重过轻的患者体重增加并变为正常体重，25%正常体重的患者和75%肥胖的患者体重增加；其余患者的BMI保持稳定。随访BMI在统计学上高于初始BMI（平均17.17对15.62，p<0.0001）。
乳糜泻患者在诊断时的BMI低于当地人群。在GFD饮食下，所有类别的BMI均显著增加。
