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在一家大型省级心脏外科中心进行主动脉瓣和二尖瓣置换手术后的长期非机构化生存及再次住院情况

Long-term non-institutionalized survival and rehospitalization after surgical aortic and mitral valve replacements in a large provincial cardiac surgery centre.

作者信息

Yan Weiang, Shah Pallav, Hiebert Brett, Pozeg Zlatko, Ghorpade Nitin, Singal Rohit K, Manji Rizwan A, Arora Rakesh C

机构信息

Section of Cardiac Surgery, Department of Surgery, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada.

Cardiac Sciences Program, Winnipeg Regional Health Authority, Winnipeg, MB, Canada.

出版信息

Interact Cardiovasc Thorac Surg. 2018 Jul 1;27(1):131-138. doi: 10.1093/icvts/ivy018.

Abstract

OBJECTIVES

Long-term quality of life following open surgical valve replacement is an increasingly important outcome to patients and their caregivers. This study examines non-institutionalized survival and rehospitalization within our surgical aortic valve replacement (AVR) and mitral valve replacement (MVR) populations.

METHODS

A retrospective single-centre study of all consecutive open surgical valve replacements between 1995 and 2014 was undertaken. Clinical data were linked to provincial administrative data for 3219 patients who underwent AVR, MVR or double (aortic and mitral) valve replacement with or without concomitant coronary artery bypass grafting (CABG). Non-institutionalized survival and cumulative incidence of rehospitalization was examined up to 15 years.

RESULTS

Follow-up was complete for 96.9% of the 2146 patients who underwent AVR ± CABG (66.7% of the overall cohort), 878 who underwent MVR ± CABG (27.3%) and 195 who underwent double (aortic and mitral) valve replacement ± CABG (6.0%) with a median follow-up time of 5.6 years. Overall non-institutionalized survival was 35.4% at 15 years, and the cumulative incidence of rehospitalization was 34.4%, 63.2% and 87.0% at 1, 5 and 15 years, respectively, without significant differences between valve procedure cohorts. Both non-institutionalized survival and cumulative incidence of rehospitalization improved in more recent eras, despite increasing age and comorbidities.

CONCLUSIONS

Non-institutionalized survival and rehospitalization data for up to 15 years suggest good functional outcomes long after surgical AVR and/or MVR. Continued improvements are seen in these metrics over the past 2 decades. This provides a unique insight into the quality of life after surgical valve replacement in the ageing demographics with valvular heart disease.

摘要

目的

对于患者及其护理人员而言,开胸手术瓣膜置换术后的长期生活质量是一项日益重要的结果指标。本研究调查了接受外科主动脉瓣置换术(AVR)和二尖瓣置换术(MVR)患者的非机构化生存情况及再次住院情况。

方法

对1995年至2014年间所有连续接受开胸手术瓣膜置换术的患者进行了一项回顾性单中心研究。临床数据与省级行政数据相关联,涉及3219例接受AVR、MVR或双瓣(主动脉瓣和二尖瓣)置换术(无论是否同时进行冠状动脉旁路移植术(CABG))的患者。对非机构化生存情况及再次住院的累积发生率进行了长达15年的调查。

结果

2146例接受AVR±CABG的患者中有96.9%(占整个队列的66.7%)、878例接受MVR±CABG的患者(占27.3%)以及195例接受双瓣(主动脉瓣和二尖瓣)置换术±CABG的患者(占6.0%)完成了随访,中位随访时间为5.6年。15年时总体非机构化生存率为35.4%,1年、5年和15年时再次住院的累积发生率分别为34.4%、63.2%和87.0%,不同瓣膜手术队列之间无显著差异。尽管患者年龄和合并症增加,但在最近几年,非机构化生存率和再次住院的累积发生率均有所改善。

结论

长达15年的非机构化生存和再次住院数据表明,外科AVR和/或MVR术后很长时间功能结局良好。在过去20年中,这些指标持续改善。这为患有瓣膜性心脏病的老年人群体外科瓣膜置换术后的生活质量提供了独特的见解。

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