Cell Biology and Physiology Center, National Heart Lung and Blood Institute, National Institutes of Health, Building 50, Room 2306, 9000 Rockville Pike, Bethesda, MD 20892, USA.
Curr Biol. 2018 Feb 19;28(4):R155-R157. doi: 10.1016/j.cub.2018.01.013.
Cytotoxic T cells and natural killer cells defend us against disease by secreting lytic granules. Whether actin facilitates or thwarts lytic granule secretion has been an open question. Recent results now indicate that the answer depends on the maturation stage of the immune cell-target cell contact.
细胞毒性 T 细胞和自然杀伤细胞通过分泌裂解颗粒来抵御疾病。肌动蛋白是促进还是阻碍裂解颗粒的分泌一直是一个悬而未决的问题。最近的研究结果表明,答案取决于免疫细胞-靶细胞接触的成熟阶段。