口服洗必泰预防重症监护病房医院获得性肺炎和呼吸机相关性肺炎的有效性：系统评价概述
Effectiveness of oral chlorhexidine for the prevention of nosocomial pneumonia and ventilator-associated pneumonia in intensive care units: Overview of systematic reviews.
作者信息
Rabello F, Araújo V E, Magalhães Sms
机构信息
Department of Social and Preventive Dentistry, College of Dentistry, Federal University of Minas Gerais, Minas Gerais, Brazil.
Department of Dentistry, Institute of Biological Sciences of Health, Pontifical Catholic University of Minas Gerais, Brazil.
出版信息
Int J Dent Hyg. 2018 Nov;16(4):441-449. doi: 10.1111/idh.12336. Epub 2018 Feb 23.
OBJECTIVE
To summarize evidence regarding the effectiveness of using chlorhexidine for oral healthcare on patients in the intensive care unit for the prevention of nosocomial pneumonia and ventilator-associated pneumonia.
METHODS
This overview of systematic reviews was developed using articles found in PUBMED, Cochrane Library, LILACS, CRD, CINHAL, manual search and grey literature.
RESULTS
Of the total 16 systematic reviews, 14 included meta-analysis. Most of them were classified with high methodological quality. In seven systematic reviews, chlorhexidine was effective for prevention of nosocomial pneumonia and ventilator-associated pneumonia in adult population in cardiothoracic intensive care unit. The effectiveness was contradictory with other population patients in intensive care units.
CONCLUSION
Chlorhexidine has proven to be effective for the prevention of NP among adult populations in cardiothoracic ICU. In ICUs with patients who have varied clinical-surgical conditions, the effectiveness of chlorhexidine for the prevention of PN and VAP was inconclusive.
目的
总结关于在重症监护病房使用洗必泰进行口腔护理对预防医院获得性肺炎和呼吸机相关性肺炎有效性的证据。
方法
本系统评价概述通过在PUBMED、Cochrane图书馆、LILACS、CRD、CINHAL中检索到的文章、手工检索及灰色文献来完成。
结果
在总共16篇系统评价中，14篇纳入了荟萃分析。其中大多数被归类为方法学质量高。在7篇系统评价中，洗必泰对心胸外科重症监护病房成年患者预防医院获得性肺炎和呼吸机相关性肺炎有效。其有效性在其他重症监护病房的患者人群中存在矛盾。
结论
已证明洗必泰对心胸外科重症监护病房成年人群预防医院获得性肺炎有效。在有各种临床手术情况患者的重症监护病房中，洗必泰预防肺炎和呼吸机相关性肺炎的有效性尚无定论。
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