依鲁替尼诱发的嗜中性皮病。

Ibrutinib-Induced Neutrophilic Dermatosis.

作者信息

El Halabi Layal, Cherif-Rebai Khadija, Michot Jean-Marie, Ghez David

机构信息

Département d'Hématologie, Institut Gustave Roussy, Villejuif, France.

Département de biologie et pathologie médicales, Institut Gustave Roussy, Villejuif, France.

出版信息

Am J Dermatopathol. 2018 Mar;40(3):198-200. doi: 10.1097/DAD.0000000000000862.

DOI:10.1097/DAD.0000000000000862

PMID:29473834

Abstract

We report the case of a 64-year-old woman treated with ibrutinib for a chronic lymphocytic leukemia with 17p deletion, who developed several erythematous, painful, and papulo-nodular skin lesions in the limbs, neck, and face. The skin biopsy was consistent with the diagnosis of neutrophilic dermatosis. Rechallenge with ibrutinib at full dose was followed by the recurrence of the same skin lesions, strongly suggesting a direct relationship.

摘要

我们报告了一例64岁女性患者，她因17p缺失的慢性淋巴细胞白血病接受依鲁替尼治疗，之后在四肢、颈部和面部出现了多处红斑、疼痛性丘疹结节性皮肤病变。皮肤活检结果符合嗜中性皮肤病的诊断。再次全剂量使用依鲁替尼后，相同的皮肤病变复发，强烈提示存在直接关联。