a Faculty of Sport Science and Physical Education, University of Coimbra, Estádio Universitário de Coimbra, Avenida Conímbriga, Pavilhão 3. 3040-248, Coimbra, Portugal.
b Applied Cognitive Research NCSEM Loughborough University, Loughborough, UK Epinal Way, Loughborough, LE11 3TU, Leicestershire, UK.
Appl Physiol Nutr Metab. 2018 Jul;43(7):733-741. doi: 10.1139/apnm-2017-0775. Epub 2018 Feb 23.
Immunosenescence contribute to increase the blood-brain barrier (BBB) permeability, leading cognitive impairment and neurodegeneration. Thus, we investigated the anti-inflammatory effect of exercise and taurine supplementation on peripheral markers of BBB, inflammation, and cognition of elderly women. Forty-eight elderly women (age, 83.58 ± 6.9 years) participated in the study, and were allocated into combined exercise training (CET: n = 13), taurine supplementation (TAU: n = 12), exercise training associated with taurine (CET+TAU: n = 11), or control (CG: n = 12) groups. Exercise was applied twice a week (multi-modal exercise). Taurine ingestion was 1.5 g., once a day. Participants were evaluated before and after 14-weeks of intervention. Plasma levels of interleukin (IL)-1β, IL-1ra, IL-6, IL-10, IL-17, tumor necrosis factor alpha (TNF-α), and serum concentration of S100β and neuron specific enolase (NSE) were determined. The mini mental state examination (MMSE) was also applied. Concentrations of S100β were maintained in all intervention groups, while a subtle increase in the CG was found. NSE levels increased only in TAU group (p < 0.05). CET reduced TNF-α, IL-6, and IL-1β/IL-1ra, IL-6/IL10, and TNF-α/IL-10 ratios (p < 0.05). TAU decreased the IL-1β/IL-1ra ratio (p < 0.05). MMSE score increased only in the CET+TAU group (p < 0.05). Multiple regression analysis showed that there was a trend for changes in IL-1β and the Charlson Comorbidity Index to be independently associated with changes in S100β. Exercise and taurine decreased inflammation, and maintained the BBB integrity in elderly women. Exercise emerged as an important tool to improve brain health even when started at advanced ages.
免疫衰老导致血脑屏障（BBB）通透性增加，从而导致认知障碍和神经退行性变。因此，我们研究了运动和牛磺酸补充对老年女性外周 BBB 标志物、炎症和认知的抗炎作用。48 名老年女性（年龄 83.58 ± 6.9 岁）参与了这项研究，并被分配到联合运动训练（CET：n = 13）、牛磺酸补充（TAU：n = 12）、运动训练联合牛磺酸（CET+TAU：n = 11）或对照组（CG：n = 12）组。运动每周进行两次（多模式运动）。牛磺酸的摄入量为 1.5 克，每天一次。参与者在干预 14 周前后进行评估。测定血浆白细胞介素（IL）-1β、IL-1ra、IL-6、IL-10、IL-17、肿瘤坏死因子-α（TNF-α）以及血清 S100β 和神经元特异性烯醇化酶（NSE）浓度。还应用了简易精神状态检查（MMSE）。所有干预组的 S100β 浓度均保持稳定，而 CG 组则略有增加。只有 TAU 组的 NSE 水平升高（p < 0.05）。CET 降低了 TNF-α、IL-6 和 IL-1β/IL-1ra、IL-6/IL10 和 TNF-α/IL-10 比值（p < 0.05）。TAU 降低了 IL-1β/IL-1ra 比值（p < 0.05）。只有 CET+TAU 组的 MMSE 评分增加（p < 0.05）。多元回归分析显示，IL-1β 和 Charlson 合并症指数的变化与 S100β 的变化有趋势相关。运动和牛磺酸可降低炎症反应，维持老年女性 BBB 的完整性。即使在老年时开始运动，也是改善大脑健康的重要工具。
