大唾液腺癌患者的健康相关生活质量
Health-related quality of life in patients with major salivary gland carcinoma.
作者信息
Becker Christoph, Pfeiffer Jens, Lange Kitty, Dahlem Kilian Konrad Kenjiro
机构信息
Department of Otorhinolaryngology-Head and Neck Surgery, University Medical Centre Freiburg, Killianstrasse 5, 79106, Freiburg, Germany.
出版信息
Eur Arch Otorhinolaryngol. 2018 Apr;275(4):997-1003. doi: 10.1007/s00405-018-4914-7. Epub 2018 Feb 24.
PURPOSE
To evaluate the health-related quality of life (QOL) in patients with major salivary gland carcinoma (MSGC).
METHODS
45 patients with MSGC completed the University of Washington Quality of Life (UWQOL) questionnaire. Results and factors influencing quality of life were analyzed using Mann-Whitney U test.
RESULTS
24 patients were male, 21 patients were female, and median age was 57 years. 33 patients presented with early stage (UICC stage I or II) cancer. All patients had surgery as initial therapy. The UWQOL domains with the worst results were 'appearance', 'activity' and 'anxiety'. Factors influencing QOL were sex, tumor stage, comorbidities, follow-up time, tumor grade, postoperative radiation therapy and facial nerve dysfunction.
CONCLUSIONS
Diagnosis and treatment of MSGC has influence on overall QOL. Postoperative radiation has the greatest impact on QOL. This is one of the largest study evaluating QOL in patients with salivary gland carcinoma using the UWQOL.
目的
评估大唾液腺癌（MSGC）患者的健康相关生活质量（QOL）。
方法
45例MSGC患者完成了华盛顿大学生活质量（UWQOL）问卷。使用Mann-Whitney U检验分析生活质量的结果及影响因素。
结果
24例患者为男性，21例患者为女性，中位年龄为57岁。33例患者为早期（国际抗癌联盟I期或II期）癌症。所有患者均以手术作为初始治疗。UWQOL中结果最差的领域是“外观”“活动”和“焦虑”。影响生活质量的因素包括性别、肿瘤分期、合并症、随访时间、肿瘤分级、术后放疗和面神经功能障碍。
结论
MSGC的诊断和治疗对总体生活质量有影响。术后放疗对生活质量的影响最大。这是使用UWQOL评估唾液腺癌患者生活质量的最大规模研究之一。
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