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2016 年德国 PREP 态度:HIV 高危男男性行为者对 PREP 的认知度和接受度高。

2016 PREP attitudes in Germany: high awareness and acceptance in MSM at risk of HIV.

机构信息

Department of Medicine II, University Hospital Klinikum Rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, Munich, Germany.

German Association of Physicians Specialized in HIV Care (Dagnä e.V.), Nuernberger Str. 16, 10789, Berlin, Germany.

出版信息

Infection. 2018 Jun;46(3):405-408. doi: 10.1007/s15010-018-1127-3. Epub 2018 Feb 24.

Abstract

PRUPOSE

To examine current risk behavior, awareness, experience, and attitudes towards pre-exposure-prophylaxis (PrEP), and to estimate a potential impact on the prevention of HIV transmission among HIV-negative MSM in Germany. PrEP was not officially licensed at the time of survey.

METHODS

Web-based questionnaire from 03-06/2016. Potential participants were informed through social media, flyers, and advertisements. Risk contacts were defined as unprotected sexual intercourse under the influence of recreational drugs in the past 6 months.

RESULTS

In total, 1208 subjects participated, 342 subjects were excluded for being HIV-infected or non-MSM, leaving 866 subjects to be evaluated in this analysis. Mean age was 37.0 ± 10.4 years. 593 participants (68.5%) were tested for HIV within the past 12 months. A total of 206 STDs in the past 6 months were reported by 144 (16.6%). Aware of PrEP was 748 (86.4%) respondents, while 65.1% reported willingness to use it. Risk behavior was significantly associated with higher PrEP acceptance (OR 2.90, 95% CI 2.14-3.90), as was a history of STDs (OR 1.85, 95% CI 1.17-2.91). The use of condoms would forgo 52.3% of subjects if taking PrEP. Sixty-five respondents (7.5%) reported PrEP use. Only 19 (29.2%) had accessed PrEP under medical supervision. PrEP use was reported by 14.8% with > 5 risk contacts in the past 6 months, compared to 6.3% with one risk contact (p < 0.001).

CONCLUSION

We found a high PrEP awareness and acceptance, especially among subgroups of MSM at highest risk of HIV infection. Structured access and availability of PrEP to this population may have an important impact on the HIV epidemic in Germany.

摘要

目的

调查德国 HIV 阴性男男性行为者(MSM)当前的风险行为、预防意识、PrEP 的使用经验和态度,并评估 PrEP 对预防 HIV 传播的潜在影响。在调查时,PrEP 尚未获得官方许可。

方法

本研究采用基于网络的问卷形式,于 2016 年 3 月至 6 月进行。通过社交媒体、传单和广告来告知潜在参与者。风险接触定义为过去 6 个月内因使用娱乐性药物而发生的无保护性行为。

结果

共纳入 1208 名参与者,其中 342 名因 HIV 感染或非 MSM 而被排除,最终有 866 名参与者纳入本分析。参与者的平均年龄为 37.0±10.4 岁。593 名(68.5%)参与者在过去 12 个月内接受过 HIV 检测。144 名(16.6%)参与者在过去 6 个月内报告了 206 例性传播疾病(STD)。748 名(86.4%)受访者知晓 PrEP,65.1%的人表示愿意使用。风险行为与更高的 PrEP 接受率显著相关(OR 2.90,95%CI 2.14-3.90),性病史(OR 1.85,95%CI 1.17-2.91)也是如此。如果使用 PrEP,65.3%的人将不再使用避孕套。有 65 名(7.5%)受访者报告使用 PrEP,其中仅 19 名(29.2%)在医疗监督下使用 PrEP。在过去 6 个月内有超过 5 次风险接触的参与者中,有 14.8%报告使用 PrEP,而仅有 1 次风险接触的参与者中,有 6.3%报告使用 PrEP(p<0.001)。

结论

我们发现,参与者对 PrEP 的认知度和接受度较高,尤其是 HIV 感染风险最高的 MSM 亚组。为该人群提供结构化的 PrEP 途径和可及性可能对德国的 HIV 流行产生重要影响。

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