当妇女生理机能衰退（即绝经）时，她们更容易受到β-淀粉样蛋白的影响。Tokishakuyakusan 可改善去卵巢合并β-淀粉样蛋白所致大鼠的空间记忆障碍。

Tokishakuyakusan ameliorates spatial memory deficits induced by ovariectomy combined with β-amyloid in rats.

机构信息

Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan; Department of Pharmacy, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan.

出版信息

J Pharmacol Sci. 2018 Mar;136(3):149-154. doi: 10.1016/j.jphs.2018.01.005. Epub 2018 Feb 8.

DOI:10.1016/j.jphs.2018.01.005

PMID:29478713

Abstract

Previously, we reported that ovariectomy (OVX) combined with β-amyloid peptide (Aβ) impaired spatial memory by decreasing extracellular acetylcholine (ACh) levels in the dorsal hippocampus. Here, we investigated the effect of tokishakuyakusan (TSS), a Kampo medicine, on the impairment of spatial memory induced by OVX combined with Aβ in rats. Repeated administration of TSS (300 mg/kg, p.o.) significantly decreased the number of errors in the eight-arm radial maze test. Though TSS had no effect on extracellular ACh levels at baseline, TSS significantly increased extracellular ACh levels in the dorsal hippocampus. These results suggest that TSS improves the impairment of spatial memory induced by OVX combined with Aβ by (at least in part) increasing extracellular ACh levels in the dorsal hippocampus.

摘要

先前，我们曾报道过卵巢切除术（OVX）联合β-淀粉样肽（Aβ）会降低背侧海马体的细胞外乙酰胆碱（ACh）水平，从而损害空间记忆。在此，我们研究了日本汉方药通圣散（TSS）对 OVX 联合 Aβ诱导的大鼠空间记忆损伤的影响。重复给予 TSS（300mg/kg，po）可显著减少八臂放射迷宫测试中的错误次数。虽然 TSS 对基础状态下的细胞外 ACh 水平没有影响，但 TSS 可显著增加背侧海马体的细胞外 ACh 水平。这些结果表明，TSS 通过（至少部分）增加背侧海马体的细胞外 ACh 水平，改善 OVX 联合 Aβ引起的空间记忆损伤。