慢性肾衰竭患者使用阿司匹林时治疗期血小板高反应性
[high on-treatment platelet reactivity in patients with chronic renal failure using acetylsalicylic acid].
作者信息
Horyniecki Maciej, Łącka-Gaździk Beata, Dworaczek Wojciech, Śnit Mirosław, Łabuz-Roszak Beata
机构信息
Katedra i Klinika Neurologii W Zabrzu, Śląski Uniwersytet Medyczny w Katowicach, Zabrze, Polska.
Katedra i Klinika Chorób Wewnętrznych, Diabetologii i Nefrologii, Śląski Uniwersytet Medyczny w Katowicach, Katowice, Polska.
出版信息
Wiad Lek. 2017;70(6 pt 1):1102-1107.
Cardiovascular diseases (CVD) are the most common cause of mortality in the world. Acetylsalicylic acid (ASA) is a widely used medicine in primary and secondary prevention of cardiovascular diseases. About 1-60% patients taking aspirin have high platelet reactivity (HOPR) despite aspirin treatment. HOPR is significantly more frequent in patients with chronic kidney disease (CKD) and it increases the risk of adverse cardiovascular events in these patients. The cause of HOPR in patients with CKD may be oxidative stress and inflammation. To the risk factors belong diabetes, female sex or decreased HDL cholesterol level.
心血管疾病（CVD）是全球最常见的死亡原因。乙酰水杨酸（ASA）是一种广泛用于心血管疾病一级和二级预防的药物。尽管进行了阿司匹林治疗，但仍有1%至60%服用阿司匹林的患者存在高血小板反应性（HOPR）。HOPR在慢性肾脏病（CKD）患者中更为常见，它增加了这些患者发生心血管不良事件的风险。CKD患者发生HOPR的原因可能是氧化应激和炎症。危险因素包括糖尿病、女性或高密度脂蛋白胆固醇水平降低。
Zotero 插件