Storey Susan, Gray Tamryn Fowler, Bryant Ashley Leak
Indiana University School of Nursing, Indianapolis, IN 46202.
Johns Hopkins University, School of Nursing.
Curr Geriatr Rep. 2017 Dec;6(4):247-254. doi: 10.1007/s13670-017-0227-8. Epub 2017 Oct 11.
To describe the pathology, impact of comorbidities, functional limitations, symptoms, and quality of life (QOL) related to treatment of acute myeloid leukemia (AML) in older adults.
AML is a rare aggressive hematologic disease that occurs most often in older adults. The prognosis for older patients with AML is markedly worse due to genetic mutations and patient characteristics such as comorbidities and functional limitations. Patient characteristics may influence treatment decisions, as well as impact symptoms, functional ability, health-related outcomes and (QOL).
As the population continues to age, the number of people diagnosed with AML is expected to increase. Better management of comorbidities is imperative to improving QOL and other treatment related outcomes. Prospective, longitudinal and multi-site studies are warranted to further understand the interaction between these characteristics on symptoms, outcomes and QOL.
描述与老年急性髓系白血病(AML)治疗相关的病理学、合并症的影响、功能限制、症状及生活质量(QOL)。
AML是一种罕见的侵袭性血液系统疾病,最常发生于老年人。由于基因突变以及诸如合并症和功能限制等患者特征,老年AML患者的预后明显更差。患者特征可能影响治疗决策,以及影响症状、功能能力、健康相关结局和生活质量(QOL)。
随着人口持续老龄化,预计诊断为AML的人数将会增加。更好地管理合并症对于改善生活质量和其他治疗相关结局至关重要。有必要开展前瞻性、纵向和多中心研究,以进一步了解这些特征在症状、结局和生活质量方面的相互作用。