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Measurement of Hyperglycemia and Impact on Health Outcomes in People With Cancer: Challenges and Opportunities.癌症患者高血糖的测量及其对健康结局的影响：挑战与机遇
Oncol Nurs Forum. 2017 Jul 1;44(4):E141-E151. doi: 10.1188/17.ONF.E141-E151.
2
The Effects of Exercise on Patient-Reported Outcomes and Performance-Based Physical Function in Adults With Acute Leukemia Undergoing Induction Therapy: Exercise and Quality of Life in Acute Leukemia (EQUAL).运动对接受诱导治疗的急性白血病成人患者自我报告结局及基于表现的身体功能的影响：急性白血病运动与生活质量（EQUAL）研究
Integr Cancer Ther. 2018 Jun;17(2):263-270. doi: 10.1177/1534735417699881. Epub 2017 Mar 24.
3
Healthcare Costs and Utilization for Patients Age 50 to 64 Years with Acute Myeloid Leukemia Treated with Chemotherapy or with Chemotherapy and Allogeneic Hematopoietic Cell Transplantation.50至64岁接受化疗或化疗加异基因造血细胞移植治疗的急性髓系白血病患者的医疗费用及使用情况。
Biol Blood Marrow Transplant. 2017 Jun;23(6):1021-1028. doi: 10.1016/j.bbmt.2017.02.017. Epub 2017 Mar 2.
4
Impact of Hyperglycemia and Age on Outcomes in Patients With Acute Myeloid Leukemia.高血糖和年龄对急性髓系白血病患者预后的影响
Oncol Nurs Forum. 2016 Sep 1;43(5):595-601. doi: 10.1188/16.ONF.595-601.
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Acute myeloid leukemia in the older adults.老年急性髓系白血病
Leuk Res Rep. 2016 Jun 16;6:1-7. doi: 10.1016/j.lrr.2016.06.001. eCollection 2016.
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Second line therapies in polycythemia vera: What is the optimal strategy after hydroxyurea failure?真性红细胞增多症的二线治疗：羟基脲治疗失败后最佳策略是什么？
Crit Rev Oncol Hematol. 2016 Sep;105:112-7. doi: 10.1016/j.critrevonc.2016.06.013. Epub 2016 Jun 26.
7
How I treat acute myeloid leukemia presenting with preexisting comorbidities.我如何治疗伴有基础合并症的急性髓系白血病。
Blood. 2016 Jul 28;128(4):488-96. doi: 10.1182/blood-2016-01-635060. Epub 2016 May 27.
8
Treating older patients with AML.治疗老年急性髓系白血病患者。
Leuk Suppl. 2012 Aug;1(Suppl 2):S16-7. doi: 10.1038/leusup.2012.11. Epub 2012 Aug 9.
9
Blinatumomab in acute lymphoblastic leukemia.双特异性抗体blinatumomab治疗急性淋巴细胞白血病
Expert Rev Anticancer Ther. 2016;16(3):251-3. doi: 10.1586/14737140.2016.1143778. Epub 2016 Feb 6.
10
Defining and Treating Older Adults with Acute Myeloid Leukemia Who Are Ineligible for Intensive Therapies.定义和治疗不符合强化治疗条件的老年急性髓系白血病患者。
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老年急性髓系白血病患者的合并症、身体功能和生活质量

Comorbidity, Physical Function, and Quality of Life in Older Adults with Acute Myeloid Leukemia.

作者信息

Storey Susan, Gray Tamryn Fowler, Bryant Ashley Leak

机构信息

Indiana University School of Nursing, Indianapolis, IN 46202.

Johns Hopkins University, School of Nursing.

出版信息

Curr Geriatr Rep. 2017 Dec;6(4):247-254. doi: 10.1007/s13670-017-0227-8. Epub 2017 Oct 11.

DOI:10.1007/s13670-017-0227-8
PMID:29479516
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5820770/
Abstract

PURPOSE OF REVIEW

To describe the pathology, impact of comorbidities, functional limitations, symptoms, and quality of life (QOL) related to treatment of acute myeloid leukemia (AML) in older adults.

RECENT FINDINGS

AML is a rare aggressive hematologic disease that occurs most often in older adults. The prognosis for older patients with AML is markedly worse due to genetic mutations and patient characteristics such as comorbidities and functional limitations. Patient characteristics may influence treatment decisions, as well as impact symptoms, functional ability, health-related outcomes and (QOL).

SUMMARY

As the population continues to age, the number of people diagnosed with AML is expected to increase. Better management of comorbidities is imperative to improving QOL and other treatment related outcomes. Prospective, longitudinal and multi-site studies are warranted to further understand the interaction between these characteristics on symptoms, outcomes and QOL.

摘要

综述目的

描述与老年急性髓系白血病（AML）治疗相关的病理学、合并症的影响、功能限制、症状及生活质量（QOL）。

最新发现

AML是一种罕见的侵袭性血液系统疾病，最常发生于老年人。由于基因突变以及诸如合并症和功能限制等患者特征，老年AML患者的预后明显更差。患者特征可能影响治疗决策，以及影响症状、功能能力、健康相关结局和生活质量（QOL）。

总结

随着人口持续老龄化，预计诊断为AML的人数将会增加。更好地管理合并症对于改善生活质量和其他治疗相关结局至关重要。有必要开展前瞻性、纵向和多中心研究，以进一步了解这些特征在症状、结局和生活质量方面的相互作用。