Sundberg L, Edén T, Ernstson S, Pahlitzsch R
Acta Otolaryngol Suppl. 1979;365:1-17. doi: 10.3109/00016487909124940.
This study is based upon the concept that the respiratory mucosa reacts in a uniform manner to an inflammatory stimulus. Secretory Otitis Media (SOM) may be used as a model to disclose some aspects of antibiotic penetration. Erythromycin was given for different periods of time to 108 cases of SOM where myringotomy was indicated. The middle ear effusion was aspirated and blood samples were obtained simultaneously. The concentration of erythromycin was determined by microbiological procedures. Erythromycin penetrated into the middle ear effusion. After the fourth dose the concentration was at the same level as the plasma peak level. The elimination of the drug from the middle ear secretion was considerably prolonged compared with the rapid elimination from plasma. This implies that erythromycin attains a steady state in the middle ear effusion with concentrations equal to the plasma peak level.
本研究基于这样一种概念，即呼吸道黏膜对炎症刺激会产生一致的反应。分泌性中耳炎（SOM）可作为一个模型来揭示抗生素渗透的某些方面。对108例有鼓膜切开术指征的分泌性中耳炎患者在不同时间段给予红霉素。同时抽取中耳积液并采集血样。通过微生物学方法测定红霉素的浓度。红霉素可渗透到中耳积液中。在第四次给药后，其浓度与血浆峰值水平相同。与从血浆中快速消除相比，药物从中耳分泌物中的消除明显延长。这意味着红霉素在中耳积液中达到了稳态，其浓度与血浆峰值水平相当。
