Yang Kuender D, Wu Chih-Chiang, Lee Ming-Tsung, Ou Chia-Yu, Chang Jen-Chieh, Wang Chih-Lu, Chuang Hau, Kuo Ho-Chang, Chen Chie-Pein, Hsu Te-Yao
Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan.
Institute of Biomedical Sciences, Mackay Medical College, New Taipei City, Taiwan.
Oncotarget. 2017 Nov 7;9(7):7700-7709. doi: 10.18632/oncotarget.22338. eCollection 2018 Jan 26.
Allergy sensitization may begin during the perinatal period, but predicting allergic diseases in infancy remains difficult. This study attempted to identify early predictors of childhood allergy diseases in a prospective cohort study.
In a prospective birth cohort study at southern Taiwan locating in a subtropical region, questionnaire surveys of sneezing or cough without colds at 6 and 18 months of age were recorded, and the correlation with allergy diseases was assessed at 3 and 6 years of age.
A total of 1812 pregnant women and 1848 newborn infants were prenatally enrolled, and 1543, 1344, 1236, and 756 children completed the follow-up at ages 6 months, 18 months, 3 years and 6 years, respectively. The prevalence of infant sneezing without colds at 6 and 18 months of age was 30.3% and 19.2%, respectively. The prevalence of infant cough without colds at 6 and 18 months of age was 10.6% and 5.7%, respectively. Infant sneezing without colds at 18 months of age was significantly correlated with atopic dermatitis, allergic rhinitis and asthma at 6 years of age. Infant cough without colds at 18 months of age significantly predicted asthma but not atopic dermatitis or allergic rhinitis at 6 years of age.
Infant sneezing without colds predicted all allergy diseases at 6 years of age in a subtropical country. This highlights a potential non-invasive clue in a subtropical region for the early prediction, treatment and prevention of childhood allergy diseases in infancy.
过敏致敏可能始于围产期，但预测婴儿期的过敏性疾病仍然困难。本研究试图在前瞻性队列研究中确定儿童过敏性疾病的早期预测因素。
在台湾南部亚热带地区进行的一项前瞻性出生队列研究中，记录了6个月和18个月大时无感冒症状的打喷嚏或咳嗽的问卷调查情况，并在3岁和6岁时评估了与过敏性疾病的相关性。
共有1812名孕妇和1848名新生儿在产前入组，分别有1543名、1344名、1236名和756名儿童在6个月、18个月、3岁和6岁时完成随访。6个月和18个月大时无感冒症状的婴儿打喷嚏患病率分别为30.3%和19.2%。6个月和18个月大时无感冒症状的婴儿咳嗽患病率分别为10.6%和5.7%。18个月大时无感冒症状的婴儿打喷嚏与6岁时的特应性皮炎、过敏性鼻炎和哮喘显著相关。18个月大时无感冒症状的婴儿咳嗽显著预测了6岁时的哮喘，但未预测6岁时的特应性皮炎或过敏性鼻炎。
在一个亚热带国家，18个月大时无感冒症状的婴儿打喷嚏可预测6岁时的所有过敏性疾病。这凸显了亚热带地区在婴儿期对儿童过敏性疾病进行早期预测、治疗和预防的潜在非侵入性线索。
