Chen Xiao-Ping, Shang Xiao-Sen, Wang Yan-Bin, Fu Zhi-Hua, Gao Yu, Feng Tao
Department of Cardiology, Taiyuan Central Hospital, Taiyuan, Shanxi, China.
Rev Assoc Med Bras (1992). 2017 Dec;63(12):1049-1054. doi: 10.1590/1806-9282.63.12.1049.
To explore the correlation between growth differentiation factor 15 (GDF-15) -3148C/G polymorphism and the formation of collateral circulation in acute ST-elevation myocardial infarction (STEMI) in Han population of Taiyuan area.
The present study included 92 STEMI patients and 56 normal controls based on coronary angiography; STEMI group was divided into collateral group and non-collateral group according to Rentrop's grading method. Polymerase chain reaction (PCR) and DNA sequencing methods were used to detect and analyze the GDF-15 -3148C/G polymorphism in all participants.
There was significant difference in GDF-15 -3148C/G CC and GC distribution between STEMI group and control group (p=0.009); the allele frequencies between these two groups were also significant different (p=0.016); and the risk genotype for STEMI was CC with increased OR=2.660. For STEMI group, GDF-15 -3148C/G CC and GC distribution was also significantly different between patients with and without collateral (p=0.048), and CC genotype significantly promote the formation of collateral circulation. However, there were no significant differences in allele frequencies between these two subgroups of STEMI.
There was correlation between GDF-15-3148C/G polymorphism and the formation of collateral circulation in patients with acute STEMI.
探讨生长分化因子15（GDF - 15）-3148C/G基因多态性与太原地区汉族人群急性ST段抬高型心肌梗死（STEMI）侧支循环形成的相关性。
本研究纳入92例STEMI患者和56例正常对照者，均行冠状动脉造影；STEMI组根据Rentrop分级法分为侧支循环组和无侧支循环组。采用聚合酶链反应（PCR）及DNA测序方法检测并分析所有研究对象的GDF - 15 -3148C/G基因多态性。
STEMI组与对照组GDF - 15 -3148C/G的CC和GC分布存在显著差异（p = 0.009）；两组间等位基因频率也有显著差异（p = 0.016）；STEMI的风险基因型为CC，OR值增加至2.660。对于STEMI组，有、无侧支循环患者的GDF - 15 -3148C/G的CC和GC分布也存在显著差异（p = 0.048），CC基因型显著促进侧支循环形成。然而，STEMI这两个亚组间的等位基因频率无显著差异。
急性STEMI患者GDF - 15-3148C/G基因多态性与侧支循环形成存在相关性。
