乳腺癌发病率的时空分析：2005年至2012年葡萄牙南部的一项研究

Spatiotemporal Analysis of Breast Cancer Incidence: A Study in Southern Portugal Between 2005 and 2012.

作者信息

Gomes Inês, Miranda Ana, Nunes Carla

机构信息

Epidemiology and Statistics Department, National School of Public Health, NOVA University of Lisbon, Lisbon, Portugal.

Pfizer, Porto Salvo, Portugal.

出版信息

Anticancer Res. 2018 Mar;38(3):1797-1805. doi: 10.21873/anticanres.12418.

DOI:10.21873/anticanres.12418

PMID:29491119

Abstract

AIM

To characterize the spatiotemporal patterns of breast cancer (BC) incidence in females in the area with the highest incidence rate (IR) of the country in 2005-2012.

MATERIALS AND METHODS

The BC-IR was studied using mapping techniques, analysis of spatiotemporal clusters and analysis of spatial variations in temporal trends.

RESULTS

The overall BC-IR was 119.13/10 inhabitants. The annual BC-IRs were 17.7, 156.9, 213.3 and 232.9/10 inhabitants for women diagnosed at <40, 40-49, 50-64 and ≥65 years of age. This IR increased overall (by 4.113%/year) and for the four age groups (by 5.935, 3.833, 4.114 and 2.194%/year, respectively). In patients with locoregional and metastatic disease, the IRs were 93.6 and 7.4/10 inhabitants, increasing by 6.976 and 0.303%/year, respectively. Several spatiotemporal clusters and two spatial-variations in temporal trends were detected. The Lisbon region showed high IR clusters for most groups.

CONCLUSION

This study identified critical areas of high IR and increasing trends for female BC-IR, providing evidence of heterogeneities in this area.

摘要

目的

描述2005 - 2012年该国乳腺癌发病率最高地区女性乳腺癌发病的时空模式。

材料与方法

采用绘图技术、时空聚类分析和时间趋势空间变异分析研究乳腺癌发病率。

结果

乳腺癌总体发病率为119.13/10万居民。年龄<40岁、40 - 49岁、50 - 64岁和≥65岁女性的乳腺癌年发病率分别为17.7、156.9、213.3和232.9/10万居民。总体发病率上升（每年上升4.113%），四个年龄组发病率也上升（分别为每年5.935%、3.833%、4.114%和2.194%）。局部和转移性疾病患者的发病率分别为93.6和7.4/10万居民，分别每年上升6.976%和0.303%。检测到几个时空聚类和两个时间趋势的空间变异。里斯本地区大多数组呈现高发病率聚类。