Dang Minh Huan, Wu Samuel, Sia Christopher
Department of Nephrology, Frankston Hospital, Peninsula Health, Frankston, VIC, Australia.
Oxf Med Case Reports. 2016 Aug 29;2016(8):omw057. doi: 10.1093/omcr/omw057. eCollection 2016 Aug.
Ibuprofen is widely used in the community to manage pain, inflammation and fever. In cases of prolonged and supratherapeutic ingestion of ibuprofen, renal tubular acidosis (RTA) with profound hypokalemia may occur. Although hypokalemia is known to cause rhabdomyolysis, rhabdomyolysis occurring in the setting of ibuprofen-induced RTA is rare. We present an unusual case of a 34-year-old male who presented with rhabdomyolysis in the setting of profound hypokalemia as a result of ibuprofen-induced RTA. The patient was successfully treated with fluid resuscitation, electrolyte replacement and supportive therapy. This case demonstrates a serious complication of ibuprofen and the importance of monitoring in nonprescription medications.
布洛芬在社区中广泛用于控制疼痛、炎症和发热。在长期超治疗剂量摄入布洛芬的情况下,可能会发生伴有严重低钾血症的肾小管酸中毒(RTA)。虽然已知低钾血症会导致横纹肌溶解,但在布洛芬诱导的RTA背景下发生的横纹肌溶解很少见。我们报告了一例不寻常的病例,一名34岁男性因布洛芬诱导的RTA导致严重低钾血症,并出现横纹肌溶解。该患者通过液体复苏、电解质补充和支持治疗成功治愈。该病例显示了布洛芬的一种严重并发症以及对非处方药进行监测的重要性。