Igarashi S
Nihon Sanka Fujinka Gakkai Zasshi. 1987 Feb;39(2):189-94.
We studied the significance of Early Pregnancy Factor (EPF), which appeared very soon after fertilization, on reproductive immunology. The results were as follows: EPF inhibited dose-dependently mixed lymphocyte reaction (MLR). EPF suppressed recognition phase of MLR. And EPF induced nonadherent, Thy 1.2+, Lyt 1-, Lyt 2+ regulator cells as suppressor T cells. Immunosuppressive effect of EPF was not restricted by major histocompatibility complex (MHC). Administration of anti EPF antibody in period before implantation of mice decreased the number of implantations and neonates. It suggested that EPF was important in this stage of reproduction.
我们研究了受精后很快出现的早孕因子（EPF）在生殖免疫学中的意义。结果如下：EPF剂量依赖性地抑制混合淋巴细胞反应（MLR）。EPF抑制MLR的识别阶段。并且EPF诱导非黏附性、Thy 1.2 +、Lyt 1 -、Lyt 2 +调节细胞作为抑制性T细胞。EPF的免疫抑制作用不受主要组织相容性复合体（MHC）的限制。在小鼠植入前阶段给予抗EPF抗体可减少植入数和新生仔数。这表明EPF在生殖的这一阶段很重要。
