Wu Hongying, Wei Liyan, Hao Lumei, Li Xuemei, Wang Lei, Yuan Chenglu
Qingdao Municipal Hospital (group) Shandong University Qilu Hospital (Qingdao), Qingdao, Shandong, China.
Medicine (Baltimore). 2018 Jan;97(3):e9484. doi: 10.1097/MD.0000000000009484.
Hodgkin lymphoma (HL) is a lymphoproliferative disease arising in the lymphoid tissue, which is characterized by Reed-Sternberg cells. Adenocarcinoma is the most frequent pathological type of stomach cancer. Improved survival in HL patients leads to the development of secondary malignancies. However, synchronous occurrence of these 2 malignancies is extremely rare. Here, we present a 45-year-old male complaining of a lymph node mass in the neck, without any abdominal symptoms, diagnosed as HL and gastric adenocarcinoma with hepatitis B carrier status. We treated the patient with 8 courses of pirarubicin bleomycin, vincristine, and dacarbazine (modified ABVD), and 4 courses of capecitabine therapy concurrently along with oral entecavir, as the patient survived longer than 20 months.The prognosis of multiple primary malignancies is poor because therapy is difficult, without a standard treatment. The frequency of multiple primary malignancies is increasing in recent years, and second malignancies in patients with cancer should be taken into consideration.
霍奇金淋巴瘤（HL）是一种起源于淋巴组织的淋巴增殖性疾病，其特征为里德-斯腾伯格细胞。腺癌是胃癌最常见的病理类型。HL患者生存率的提高导致了继发性恶性肿瘤的发生。然而，这两种恶性肿瘤同时出现极为罕见。在此，我们报告一名45岁男性，主诉颈部淋巴结肿块，无任何腹部症状，被诊断为HL和胃腺癌，同时为乙肝携带者。由于患者存活超过20个月，我们用8个疗程的吡柔比星、博来霉素、长春新碱和达卡巴嗪（改良ABVD）以及4个疗程的卡培他滨治疗该患者，同时口服恩替卡韦。多种原发性恶性肿瘤的预后较差，因为治疗困难且没有标准治疗方案。近年来，多种原发性恶性肿瘤的发生率在增加，癌症患者的继发性恶性肿瘤应予以考虑。
