螺旋断层放疗图像引导放疗在肺癌患者中的疗效与安全性
Efficacy and safety of image-guidance radiotherapy by helical tomotherapy in patients with lung cancer.
作者信息
Chen Xiang-Ru, Dong Jia-Nan, Zhang Fan, Yao Tian-Ling
机构信息
Department of Ultrasound, The Second Affiliated Hospital of Mudanjiang Medical University Department of Rehabilitation Comprehensive Laboratory School of Image, Mudanjiang Medical University.
出版信息
Medicine (Baltimore). 2018 Jan;97(1):e9243. doi: 10.1097/MD.0000000000009243.
This study aimed to explore the efficacy and toxicity of image-guided stereotactic body radiotherapy (IGSBR) by helical tomotherapy in patients with lung cancer among Chinese Han population.A total of 21 patients with stage I lung cancer were included. They received a total of 60 Gy factions IGSBR. The outcomes included complete response (CR), partial response (PR), stable disease (SD), progress disease (PD), overall response rate (ORR), and overall survival (OS). In addition, toxicities were also recorded in this study.Three-year CR, PR, SD, PD, ORR, and OS were 47.6%, 38.1%, 9.5%, 4.8%, 85.7%, and 48.0 months, respectively. Additionally, mild toxicities were found in this study.This study demonstrated that IGSBR is efficacious for patients with stage I lung cancer with mild toxicities among Chinese Han population.
本研究旨在探讨螺旋断层放疗引导的立体定向体部放疗（IGSBR）对中国汉族肺癌患者的疗效和毒性。共纳入21例I期肺癌患者。他们接受了总计60 Gy分次的IGSBR治疗。观察指标包括完全缓解（CR）、部分缓解（PR）、疾病稳定（SD）、疾病进展（PD）、总缓解率（ORR）和总生存期（OS）。此外，本研究还记录了毒性反应。三年的CR、PR、SD、PD、ORR和OS分别为47.6%、38.1%、9.5%、4.8%、85.7%和48.0个月。此外，本研究中发现了轻度毒性反应。本研究表明，IGSBR对中国汉族I期肺癌患者有效，且毒性反应较轻。
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