CSB：一种新兴的癌症治疗可操作靶点。
CSB: An Emerging Actionable Target for Cancer Therapy.
作者信息
Proietti-De-Santis Luca, Balzerano Alessio, Prantera Giorgio
机构信息
Unit of Molecular Genetics of Aging and Laboratory of Epigenetics, Department of Ecology and Biology, University of Tuscia, 01100 Viterbo, Italy.
Unit of Molecular Genetics of Aging and Laboratory of Epigenetics, Department of Ecology and Biology, University of Tuscia, 01100 Viterbo, Italy.
出版信息
Trends Cancer. 2018 Mar;4(3):172-175. doi: 10.1016/j.trecan.2018.01.005. Epub 2018 Feb 23.
The DNA repair protein Cockayne syndrome group B (CSB) is frequently found overexpressed in cancer cells. High CSB levels favor tumor cell proliferation whilst inhibiting apoptosis. Conversely, the suppression of CSB has significant anticancer effects. In this manuscript we describe CSB downregulation as a potential new therapeutic approach in cancer.
DNA修复蛋白科凯恩综合征B组（CSB）在癌细胞中经常被发现过表达。高水平的CSB有利于肿瘤细胞增殖，同时抑制细胞凋亡。相反，抑制CSB具有显著的抗癌作用。在本手稿中，我们将CSB下调描述为一种潜在的癌症新治疗方法。
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