Dumrongpisutikul Netsiri, Chuajak Ammarut, Lerdlum Sukalaya
Department of Radiology, Faculty of Medicine, Chulalongkorn University, 1873 Rama IV Road, Pathumwan, Bangkok, 10330, Thailand.
Department of Radiology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
Pediatr Radiol. 2018 May;48(5):694-700. doi: 10.1007/s00247-018-4070-7. Epub 2018 Mar 6.
Magnetic resonance imaging (MRI) is used for neuroradiologic evaluation of patients with idiopathic growth hormone deficiency (IGHD).
To compare pituitary height and morphology at MRI between patients with IGHD and controls.
This retrospective study was conducted in pediatric patients, 3 years-15 years old, who had had brain MRI with non-contrast-enhanced midsagittal T1-weighted images. These images were measured for pituitary height and morphology of the pituitary gland including shape, stalk and posterior pituitary bright spot was evaluated.
One hundred and nineteen patients were included, with 49 and 70 patients assigned to the study and control groups, respectively. Mean pituitary height was significantly less in the IGHD group than in the control group (3.81 mm±1.38 vs. 4.92 mm±1.13, retrospectively; P<0.001). Subgroup analysis revealed a significant difference in the pituitary height between groups in the prepubertal (8-10 years) and pubertal (11-13 years) periods (P=0.039 and P=0.006, respectively) and a trend toward significance in the postpubertal period (P=0.053). There was a significant difference in pituitary shape between IGHD and controls when combining grades III, IV and V (P=0.007). Other abnormal MRI findings of the pituitary stalk and posterior bright spot were significantly more often observed in the IGHD group (P<0.05).
Pituitary height was significantly smaller in patients with IGHD than in controls during prepuberty and puberty. Abnormal concave superior contour, hypoplastic stalk and absent/ectopic posterior bright spot were observed significantly more often among patients with IGHD.
磁共振成像（MRI）用于特发性生长激素缺乏症（IGHD）患者的神经放射学评估。
比较IGHD患者与对照组在MRI检查时的垂体高度和形态。
本回顾性研究纳入了3至15岁的儿科患者，这些患者均接受了未增强的矢状面T1加权脑MRI检查。测量这些图像的垂体高度，并评估垂体形态，包括形状、垂体柄和垂体后叶高信号。
共纳入119例患者，其中49例和70例分别被分配到研究组和对照组。IGHD组的平均垂体高度显著低于对照组（回顾性分析：3.81 mm±1.38 vs. 4.92 mm±1.13；P<0.001）。亚组分析显示，青春期前（8至10岁）和青春期（11至13岁）两组间垂体高度存在显著差异（分别为P=0.039和P=0.006），青春期后差异有统计学意义的趋势（P=0.053）。将III、IV和V级合并后，IGHD组与对照组的垂体形状存在显著差异（P=0.007）。IGHD组垂体柄和垂体后叶高信号的其他异常MRI表现明显更常见（P<0.05）。
IGHD患者在青春期前和青春期的垂体高度显著小于对照组。IGHD患者中，异常的上轮廓凹陷、垂体柄发育不全以及垂体后叶高信号缺如/异位的情况明显更常见。
