奥氮平所致及利培酮所致白细胞减少症：一例协同不良反应病例？
Olanzapine-induced and Risperidone-induced Leukopenia: A Case of Synergistic Adverse Reaction?
作者信息
Woon Luke Sy-Cherng, Tee Chun Keat, Gan Lydia Lay Yen, Deang Kanit Tha, Chan Lai Fong
机构信息
WOON, TEE, DEANG, and CHAN: Department of Psychiatry, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia GAN: Department of Pharmacy, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia.
出版信息
J Psychiatr Pract. 2018 Mar;24(2):121-124. doi: 10.1097/PRA.0000000000000292.
Leukopenia is a known hematological side effect of atypical antipsychotics. We report a case of an antipsychotic-naive patient with schizophrenia who developed leukopenia after a single dose of olanzapine, which worsened during subsequent treatment with risperidone. Normalization of the white blood cell counts occurred within 24 hours of risperidone discontinuation. Possible synergistic mechanisms underlying olanzapine-induced and risperidone-induced leukopenia are discussed. This case highlights the challenges in identifying and managing nonclozapine antipsychotic-induced leukopenia in a susceptible patient.
白细胞减少是已知的非典型抗精神病药物的血液学副作用。我们报告一例未使用过抗精神病药物的精神分裂症患者，在单次服用奥氮平后出现白细胞减少，在随后使用利培酮治疗期间病情恶化。在停用利培酮24小时内白细胞计数恢复正常。本文讨论了奥氮平诱导和利培酮诱导白细胞减少的潜在协同机制。该病例凸显了在易感患者中识别和管理非氯氮平抗精神病药物诱导的白细胞减少的挑战。
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