Hutopilă Ionuţ, Constantin A, Copăescu Cătălin
Chirurgia (Bucur). 2018 Jan-Feb;113(1):101-107. doi: 10.21614/chirurgia.113.1.101.
Obesity has significantly increased in the last decades and metabolic (bariatric) surgery has been extended accordingly. Clinical manifestations of Gastroesophageal reflux disease (GERD) are frequent in the obese population but the presence of GERD premises (i.e. Hiatala hernia) or complications in asymptomatic patients undergoing metabolic surgery is unclear.
(1) to identify gastroesophageal reflux condition or complications in patients undergoing metabolic surgery. (2) Study the correlations of the clinical symptoms of GERD with the preoperative radiological and endoscopic findings. All the consecutive patients (GERD symptomatic or not) undergoing metabolic surgery in a Bariatric Center of Excellence between December, 2015 and May 2016 were included in a prospective study. A multidisciplinary team evaluated all the patients within the bariatric surgery program. Clinical evaluation, radiological and endoscopic investigations were performed to all the included patients. The patients who previously had anti-reflux or bariatric surgery were excluded. Four-hundred-forty-eight consecutive patients were enrolled into the study. The mean age of patients was 41.04 (+-11.15) years, and 29% of them were men. The mean BMI was 39.96 (+-8.17) kg/m2. Symptoms of GERD were recorded only in 93 of the patients (20.76%) while endoscopic examination revealed esophagitis in 139 (31,03%) patients (107 Grade A, 28 Grade B, 3 Grade C, 1 Grade D. Barrett esophagus was suspected in 5 patients but histologic confirmation (gastric metaplasia) was recorded only in 2 patients (0.44%). Hiatal hernia was revealed by endoscopy and radiology in 119 (26,56%) and 112 patients (25%). 62% of the patients presenting esophagitis (86/139) had no pre-operative symptom of GERD, meaning that a significant number of the asymptomatic patients undergoing metabolic surgery may present consequences of gastro-esophageal reflux. The study demonstrates that GERD is more frequent then expected in asymptomatic obese patients undergoing metabolic surgery. The clinical impact of these findings is important for the proper procedure selection and for a correct evaluation of the postoperative evolution.
在过去几十年中,肥胖显著增加,代谢(减重)手术也相应得到推广。胃食管反流病(GERD)的临床表现在肥胖人群中很常见,但 GERD 前提条件(即食管裂孔疝)的存在或接受代谢手术的无症状患者的并发症尚不清楚。
(1)确定接受代谢手术患者的胃食管反流情况或并发症。(2)研究 GERD 临床症状与术前影像学和内镜检查结果的相关性。2015 年 12 月至 2016 年 5 月期间,在一家卓越减重中心接受代谢手术的所有连续患者(无论是否有 GERD 症状)均纳入一项前瞻性研究。一个多学科团队在减重手术项目中对所有患者进行评估。对所有纳入患者进行临床评估、影像学和内镜检查。排除既往有抗反流或减重手术史的患者。连续 448 例患者纳入研究。患者平均年龄为 41.04(±11.15)岁,其中 29%为男性。平均体重指数为 39.96(±8.17)kg/m²。仅 93 例患者(20.76%)记录有 GERD 症状,而内镜检查显示 139 例患者(31.03%)有食管炎(107 例为 A 级,28 例为 B 级,3 例为 C 级,1 例为 D 级。5 例患者怀疑有巴雷特食管,但仅 2 例患者(0.44%)有组织学证实(胃化生)。内镜检查和影像学检查分别发现 119 例(26.56%)和 112 例患者(25%)有食管裂孔疝。62%的食管炎患者(86/139)术前无 GERD 症状,这意味着大量接受代谢手术的无症状患者可能存在胃食管反流的后果。该研究表明,在接受代谢手术的无症状肥胖患者中,GERD 比预期更常见。这些发现的临床影响对于正确选择手术方法和正确评估术后进展很重要。