脂质体包埋富勒烯衍生物与光天线分子组合提高光动力活性。
Improvement of Photodynamic Activity of Lipid-Membrane-Incorporated Fullerene Derivative by Combination with a Photo-Antenna Molecule.
机构信息
Department of Applied Chemistry, Graduate School of Engineering, Hiroshima University, 1-4-1 Kagamiyama, Higashi-Hiroshima, 739-8527, Japan.
Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, 739-8530, Japan.
出版信息
Chemistry. 2018 May 23;24(29):7335-7339. doi: 10.1002/chem.201800674. Epub 2018 Apr 6.
The weak absorbance of pristine C , C , and fullerene derivatives at wavelengths over 600 nm hampers the use of these molecules as photosensitizers (PSs) for photodynamic therapy (PDT). The coexistence of light-harvesting antenna molecules with a fullerene derivative in lipid membrane bilayers solved this issue. By controlling the location of the C derivative in the lipid membrane, the liposomal dyad system for PDT improved the photodynamic activity via an efficient photoenergy transfer from antenna molecules to the fullerene derivative. The photodynamic activity was found to be much higher than those of dyad systems using pristine C and C .
原始 C 60 、 C 70 和富勒烯衍生物在 600nm 以上波长处的吸光度较弱，这限制了这些分子作为光敏剂（PS）用于光动力疗法（PDT）的应用。在脂质膜双层中，将光捕获天线分子与富勒烯衍生物共存解决了这个问题。通过控制 C 衍生物在脂质膜中的位置，脂质体偶联体系统通过从天线分子到富勒烯衍生物的有效光能转移提高了光动力活性。研究发现，该光动力活性远高于使用原始 C 60 和 C 70 的偶联体系统。
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