女性觉醒性卒中与睡眠呼吸障碍无关。
Wake-up stroke is not associated with sleep-disordered breathing in women.
作者信息
Brown Devin L, Li Chengwei, Chervin Ronald D, Case Erin, Garcia Nelda M, Tower Susan D, Lisabeth Lynda D
机构信息
Stroke Program (DLB, CL, EC, NMG, LDL) and Sleep Disorders Center and Department of Neurology (RDC), University of Michigan Medical School; Department of Epidemiology (CL, EC, NMG, LDL), University of Michigan School of Public Health, Ann Arbor; and Corpus Christi physician (SDT), TX.
出版信息
Neurol Clin Pract. 2018 Feb;8(1):8-14. doi: 10.1212/CPJ.0000000000000412.
BACKGROUND
We sought to investigate the frequency of wake-up stroke (WUS) and its association with sleep-disordered breathing (SDB) in women.
METHODS
Within a population-based study, women with acute ischemic stroke were asked about their stroke symptom onset time. SDB screening was performed with the well-validated ApneaLink Plus device; SDB was defined by a respiratory event index ≥10. Logistic regression was used to test the association between SDB presence and severity and WUS unadjusted and adjusted for potential confounders including prestroke depression and sleep duration.
RESULTS
Among 466 participants, the median age was 67.0 years (interquartile range [IQR] 58.0, 77.0), 55% were Mexican American, and the median initial NIH Stroke Scale score was 3.0 (IQR 1.0, 6.0). Stroke symptom onset occurred during nocturnal sleep (25.3%), during a nap (3.9%), during wakefulness (65.9%), or unknown (4.9%). In those with SDB screening performed (n = 259), a median of 11 days (IQR 5, 17) poststroke, WUS was not associated with the presence or severity (respiratory event index) of SDB in unadjusted or adjusted analysis.
CONCLUSIONS
In this population-based study, WUS represented about 30% of all generally mild severity ischemic strokes in women and was not associated with SDB.
背景
我们试图调查女性苏醒期卒中（WUS）的发生率及其与睡眠呼吸障碍（SDB）的关联。
方法
在一项基于人群的研究中，询问急性缺血性卒中女性患者的卒中症状发作时间。使用经过充分验证的ApneaLink Plus设备进行SDB筛查；SDB定义为呼吸事件指数≥10。采用逻辑回归分析来检验SDB的存在及严重程度与WUS之间的关联，分析时未调整以及调整了包括卒中前抑郁和睡眠时间等潜在混杂因素。
结果
466名参与者中，年龄中位数为67.0岁（四分位间距[IQR]为58.0, 77.0），55%为墨西哥裔美国人，初始美国国立卫生研究院卒中量表（NIH Stroke Scale）评分中位数为3.0（IQR 1.0, 6.0）。卒中症状发作发生在夜间睡眠期间（25.3%）、午睡期间（3.9%）、清醒期间（65.9%）或情况不明（4.9%）。在进行了SDB筛查的患者中（n = 259），卒中后中位数11天（IQR 5, 17），在未调整或调整分析中，WUS与SDB的存在或严重程度（呼吸事件指数）均无关联。
结论
在这项基于人群的研究中，WUS约占女性所有一般轻度缺血性卒中的30%，且与SDB无关。
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