Department of Nuclear Medicine, Centre Hospitalier Universitaire Bichat, Assistance Publique - Hôpitaux de Paris, Département Hospitalo-Universitaire FIRE, Inserm 1148, Université Paris Diderot, Paris, France.
J Nucl Cardiol. 2019 Aug;26(4):1266-1268. doi: 10.1007/s12350-018-1247-2. Epub 2018 Mar 8.
Important progresses in the management of patients with human immunodeficiency virus, in particular the advent of new anti-retroviral therapies (ART), have turned this rapidly fatal condition into a controllable chronic disease with a life expectancy that approaches the one from the general population. Cardiovascular diseases have now become one of the leading causes of non-HIV-related mortality in this population. Several factors including the presence of HIV in the vascular wall and the development of dyslipidemia and alteration in body fat distribution under ART might play a role the progression of atherosclerosis in HIV-infected patients. The use of imaging biomarkers may help to identify the factors associated with an increased risk of cardiovascular events and select high-risk patients who will benefit the most from the early implementation of preventive treatments.
在人类免疫缺陷病毒（HIV）患者的管理方面取得了重要进展，特别是新型抗逆转录病毒疗法（ART）的出现，已将这种迅速致命的疾病转变为可控制的慢性疾病，其预期寿命接近普通人群。心血管疾病现在已成为该人群中与 HIV 无关的主要死亡原因之一。包括 HIV 在血管壁中的存在、ART 下血脂异常和体脂肪分布改变在内的多种因素可能会影响 HIV 感染患者的动脉粥样硬化进展。影像学生物标志物的应用可能有助于确定与心血管事件风险增加相关的因素，并选择最能从早期预防治疗中获益的高危患者。
