Jiang Xiaobing, Chen Yinsheng, Zhou Zhihuan, Luo Liping, Hu Wanming, Zheng Huirong, Zhu Zhe, Wang Jian, Chen Zhongping
Department of Neurosurgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
Department of Pathology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
World Neurosurg. 2018 May;113:304-307. doi: 10.1016/j.wneu.2018.02.151. Epub 2018 Mar 8.
The pineal gland has been demonstrated to be involved in the development of mood and psychotic disorders. However, few studies have looked at the relationship between pineal region tumors and psychiatric disorders. Intracranial epidermoid cysts usually arise in the cerebellopontine angle area and are extremely rare in the pineal region. The case of pineal epidermoid cyst presenting as schizophrenia has never been reported before.
We described the case of a 23-year-old man who presented to the hospital with symptoms suggestive of schizophrenia. During work-up, he was found to have a pineal lesion on brain magnetic resonance imaging. Total resection of the tumor was subsequently performed, and pathology confirmed an epidermoid cyst. One month after surgery, the patient's psychotic symptoms significantly improved free of drug and fully returned to work 3 months postoperatively.
This case highlights the importance of including mass lesions of the pineal region in the differential diagnosis of psychotic disorders. It also provides further support that the pineal region may play a role in the pathophysiology of psychiatric diseases, although more studies will be needed to elucidate this interesting connection.
松果体已被证明与情绪和精神障碍的发生有关。然而，很少有研究关注松果体区肿瘤与精神障碍之间的关系。颅内表皮样囊肿通常发生在桥小脑角区，在松果体区极为罕见。此前从未有过松果体表皮样囊肿表现为精神分裂症的病例报道。
我们描述了一名23岁男性患者的病例，他因疑似精神分裂症症状入院。在检查过程中，脑部磁共振成像发现他有松果体病变。随后进行了肿瘤全切术，病理证实为表皮样囊肿。术后1个月，患者的精神症状明显改善，无需药物治疗，术后3个月完全恢复工作。
该病例强调了在精神障碍鉴别诊断中纳入松果体区占位性病变的重要性。这也进一步支持了松果体区可能在精神疾病的病理生理学中起作用，尽管还需要更多研究来阐明这种有趣的联系。
