School of Biological Sciences, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK.
QIMR Berghofer Medical Research Institute, Locked Bag 2000, Royal Brisbane Hospital QLD 4029, Australia; Faculty of Medicine, The University of Queensland, Level 6, Oral Health Centre (Building), Herston Road, Herston, QLD, 4006, Australia.
Trends Parasitol. 2018 Jun;34(6):524-540. doi: 10.1016/j.pt.2018.02.005. Epub 2018 Mar 8.
Hepatic fibrosis is a common pathology in various liver diseases. Hepatic stellate cells (HSCs) are the main cell type responsible for collagen deposition and fibrosis formation in the liver. Schistosomiasis is characterised by granulomatous fibrosis around parasite eggs trapped within the liver and other host tissues. This response is facilitated by the recruitment of immune cells and the activation of HSCs. The interactions between HSCs and schistosome eggs are complex and diverse, and a better understanding of these interactions could lead to improved resolution of fibrotic liver disease, including that associated with schistosomiasis. Here, we discuss recent advances in HSC biology and the role of HSCs in hepatic schistosomiasis.
肝纤维化是各种肝脏疾病的常见病理。肝星状细胞（HSCs）是肝脏中负责胶原沉积和纤维化形成的主要细胞类型。血吸虫病的特征是寄生虫卵在肝脏和其他宿主组织中被捕获时周围形成肉芽肿性纤维化。这种反应是通过免疫细胞的募集和 HSCs 的激活来促进的。HSCs 和血吸虫卵之间的相互作用是复杂多样的，更好地了解这些相互作用可能会导致纤维化性肝病的改善，包括与血吸虫病相关的肝病。在这里，我们讨论 HSC 生物学的最新进展以及 HSCs 在肝血吸虫病中的作用。
