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披着羊皮的狼:伪装成脑膜瘤的颅内放线菌病。

Wolf in Sheep's clothing: Intracranial actinomycosis masquerading as meningioma.

作者信息

Deora Harsh, Beniwal Manish, Rao Shilpa, Rao K V L N, Vikas V, Somanna Sampath

机构信息

Department of Neurosurgery, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, Karnataka, India.

出版信息

Surg Neurol Int. 2018 Feb 14;9:39. doi: 10.4103/sni.sni_445_17. eCollection 2018.

Abstract

BACKGROUND

is a gram-positive non-acid-fast bacterium and is the most common causative agent of actinomycosis. It usually presents as a brain abscess via a secondary spread from the cervicofacial region or lungs. However, presentation as an lesion with bone involvement out of proportion to brain parenchyma is rare and needs to be acknowledged.

CASE DESCRIPTION

We report a case of intracranial lesion in a 47-year-old female with restriction of mouth opening and right third nerve palsy for 1 year. Imaging showed hyperostosis of the maxilla, temporal base, sphenoid, and zygoma with dural thickening suggestive of a meningioma. Surgical decompression yielded a granulomatous lesion along with empirical antitubercular therapy. However, patient succumbed to the infection and final histopathology revealed actinomycosis infection.

CONCLUSION

Adequate knowledge along with clinical suspicion are the pillars to treating this unfortunate disease. Cheek swelling with bone involvement should be actively sought as risk factors. This case presents a unique opportunity to identify the fox among the sheep by elucidating the characteristic imaging findings and intraoperative view of this rare entity.

摘要

背景

[细菌名称未给出]是一种革兰氏阳性非抗酸菌,是放线菌病最常见的病原体。它通常通过从颈面部区域或肺部的继发性传播表现为脑脓肿。然而,表现为骨受累程度超过脑实质的病变较为罕见,需要引起重视。

病例描述

我们报告一例47岁女性颅内[病变名称未给出]病变,伴有张口受限和右侧动眼神经麻痹1年。影像学检查显示上颌骨、颞骨基部、蝶骨和颧骨骨质增生,硬脑膜增厚,提示为脑膜瘤。手术减压得到一个肉芽肿性病变,并给予经验性抗结核治疗。然而,患者最终死于感染,最终组织病理学检查显示为放线菌感染。

结论

充分的知识以及临床怀疑是治疗这种不幸疾病的关键。应积极寻找伴有骨受累的面颊肿胀作为危险因素。通过阐明这种罕见实体的特征性影像学表现和术中所见,本病例提供了一个在众多相似病症中识别出该疾病的独特机会。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/711b/5838848/621c1614be3a/SNI-9-39-g001.jpg

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