笑气的过去、现在和未来。
Past, present, and future of nitrous oxide.
机构信息
Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA,USA.
出版信息
Br Med Bull. 2018 Mar 1;125(1):103-119. doi: 10.1093/bmb/ldx050.
INTRODUCTION
For a drug that has been omnipresent for nearly 200 years, nitrous oxide's (N2O) future seems less certain than its illustrious past. Environmental concerns are coming to the fore and may yet outweigh important clinical benefits.
SOURCES OF DATA
After determining the scope of the review, the authors used PubMed with select phrases encompassing the words in the scope. Both preclinical and clinical reports were considered.
AREAS OF AGREEMENT
The analgesic and anaesthetic advantages of N2O remain despite a plethora of newer agents.
AREAS OF CONTROVERSY
N2O greenhouse gas effect and its inhibition of key enzymes involved in protein and DNA synthesis have provided further fuel for those intent on eliminating its further clinical use.
GROWING POINTS
The use of N2O for treatment-resistant depression has gained traction.
AREAS TIMELY FOR DEVELOPING RESEARCH
Comparative studies for N2O role in combatting the prescription opioid analgesic epidemic may well provide further clinical impetus.
简介
作为一种存在了近 200 年的药物，笑气（N2O）的未来似乎不像其辉煌的过去那样确定。环境问题日益受到关注，其重要的临床益处可能会被超越。
资料来源
在确定了审查范围后，作者使用了包含在范围中的单词的 PubMed 以及选择的短语。同时考虑了临床前和临床报告。
共识领域
尽管有大量的新型药物，但 N2O 的镇痛和麻醉优势仍然存在。
争议领域
N2O 温室气体效应及其对参与蛋白质和 DNA 合成的关键酶的抑制作用，为那些有意消除其进一步临床应用的人提供了更多的证据。
新的研究方向
N2O 治疗难治性抑郁症的应用得到了关注。
需要开展研究的领域
N2O 在对抗处方类阿片类镇痛药流行方面的作用的比较研究，很可能会为临床提供进一步的动力。
Zotero 插件