[F]FNDP的优化放射性合成，一种用于成像可溶性环氧化物水解酶（sEH）的正电子发射断层显像放射性示踪剂。
An optimized radiosynthesis of [ F]FNDP, a positron emission tomography radiotracer for imaging soluble epoxide hydrolase (sEH).
作者信息
Azad Babak Behnam, Holt Daniel P, Ravert Hayden T, Horti Andrew G, Dannals Robert F
机构信息
Division of Nuclear Medicine, Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
出版信息
J Labelled Comp Radiopharm. 2018 Jun 15;61(7):567-572. doi: 10.1002/jlcr.3620. Epub 2018 May 7.
Abstract
In this concise practitioner protocol, the radiochemical synthesis of [ F]FNDP suitable for human positron emission tomography studies is described and the results from validation productions are presented. The high specific activity radiotracer product is prepared as a sterile, apyrogenic solution that conforms to current Good Manufacturing Practice requirements.
摘要
在本简明实用方案中，描述了适用于人体正电子发射断层扫描研究的[F]FNDP的放射化学合成，并展示了验证生产的结果。高比活度放射性示踪剂产品制备成符合现行药品生产质量管理规范要求的无菌、无热原溶液。
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2
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J Labelled Comp Radiopharm. 2014 Oct;57(12):695-8. doi: 10.1002/jlcr.3241. Epub 2014 Oct 20.
3
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Prostaglandins Other Lipid Mediat. 2014 Oct;113-115:30-7. doi: 10.1016/j.prostaglandins.2014.09.003. Epub 2014 Sep 30.
4
Genetic variation in soluble epoxide hydrolase: association with outcome after aneurysmal subarachnoid hemorrhage.
J Neurosurg. 2014 Dec;121(6):1359-66. doi: 10.3171/2014.7.JNS131990. Epub 2014 Sep 12.
5
Soluble epoxide hydrolase activity regulates inflammatory responses and seizure generation in two mouse models of temporal lobe epilepsy.
Brain Behav Immun. 2015 Jan;43:118-29. doi: 10.1016/j.bbi.2014.07.016. Epub 2014 Aug 15.
6
Soluble Epoxide Hydrolase Deficiency or Inhibition Attenuates MPTP-Induced Parkinsonism.
Mol Neurobiol. 2015 Aug;52(1):187-95. doi: 10.1007/s12035-014-8833-3. Epub 2014 Aug 17.
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Distribution of soluble and microsomal epoxide hydrolase in the mouse brain and its contribution to cerebral epoxyeicosatrienoic acid metabolism.
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9
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