Adelaide Medical School and Freemasons Foundation Centre for Men's Health, University of Adelaide, Adelaide SA 5005, Australia.
South Australian Health and Medical Research Institute, Adelaide SA 5001, Australia.
Cold Spring Harb Perspect Med. 2018 Dec 3;8(12):a030478. doi: 10.1101/cshperspect.a030478.
Recent genomic analyses of metastatic prostate cancer have provided important insight into adaptive changes in androgen receptor (AR) signaling that underpin resistance to androgen deprivation therapies. Novel strategies are required to circumvent these AR-mediated resistance mechanisms and thereby improve prostate cancer survival. In this review, we present a summary of AR structure and function and discuss mechanisms of AR-mediated therapy resistance that represent important areas of focus for the development of new therapies.
最近转移性前列腺癌的基因组分析为雄激素受体 (AR) 信号适应性变化提供了重要的见解，这些变化是雄激素剥夺疗法耐药的基础。需要新的策略来规避这些 AR 介导的耐药机制，从而提高前列腺癌的生存率。在这篇综述中，我们总结了 AR 的结构和功能，并讨论了 AR 介导的治疗耐药机制，这些机制是开发新疗法的重要关注点。
