Sommer Heiko, Juliá-Hernández Francisco, Martin Ruben, Marek Ilan
Schulich Faculty of Chemistry, Technion-Israel Institute of Technology, 32000 Haifa, Israel.
Institute of Chemical Research of Catalonia (ICIQ), The Barcelona Institute of Science and Technology, Avinguda dels Països Catalans, 16, 43007 Tarragona, Spain.
ACS Cent Sci. 2018 Feb 28;4(2):153-165. doi: 10.1021/acscentsci.8b00005. Epub 2018 Feb 8.
The distant and selective activation of unreactive C-H and C-C bonds remains one of the biggest challenges in organic chemistry. In recent years, the development of remote functionalization has received growing interest as it allows for the activation of rather challenging C-H and C-C bonds distant from the initiation point by means of a "metal-walk". A "metal-walk" or "chain-walk" is defined by an iterative series of consecutive 1,2- or 1,3-hydride shifts of a metal complex along a single hydrocarbon chain. With this approach, simple building blocks or mixtures thereof can be transformed into complex scaffolds in a convergent and unified strategy. A variety of catalytic systems have been developed and refined over the past decade ranging from late-transition-metal complexes to more sustainable iron- and cobalt-based systems. As the possibilities of this field are slowly unfolding, this area of research will contribute considerably to provide solutions to yet unmet synthetic challenges.
惰性C-H和C-C键的远程选择性活化仍然是有机化学中最大的挑战之一。近年来，远程官能化的发展越来越受到关注，因为它能够通过“金属游走”的方式活化远离起始点的极具挑战性的C-H和C-C键。“金属游走”或“链游走”是指金属配合物沿着单一烃链进行一系列连续的1,2-或1,3-氢化物迁移的迭代过程。通过这种方法，可以采用一种汇聚且统一的策略将简单的结构单元或其混合物转化为复杂的骨架。在过去十年中，已经开发并优化了多种催化体系，从后过渡金属配合物到更具可持续性的铁基和钴基体系。随着该领域的可能性逐渐展现，这一研究领域将为解决尚未满足的合成挑战做出巨大贡献。
