雌性小鼠从青春期早期到成年早期恐惧调节系统的发育
Development of the fear regulation system from early adolescence to young adulthood in female mice.
作者信息
Matsuda Shingo, Matsuzawa Daisuke, Ishii Daisuke, Tomizawa Haruna, Shimizu Eiji
机构信息
Department of Pharmacotherapeutics, Showa Pharmaceutical University, 3-3165, Higashi-tamagawagakuen, Machida, Tokyo 194-8543, Japan; Department of Cognitive Behavioral Physiology, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chiba, Chiba 260-8670, Japan; Department of Ultrastructural Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo 187-8502, Japan.
Department of Cognitive Behavioral Physiology, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chiba, Chiba 260-8670, Japan; Research Center for Child Mental Development, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chiba, Chiba 260-8670, Japan.
出版信息
Neurobiol Learn Mem. 2018 Apr;150:93-98. doi: 10.1016/j.nlm.2018.03.007. Epub 2018 Mar 10.
Onset of fear-related disorders such as post-traumatic stress disorder is enhanced from adolescence until adulthood. However, the biological mechanisms underlying this vulnerability remain unclear. Therefore, we investigated contextual fear memory and extinction in 4-, 6-, 8-, 10-, and 15-week-old female mice. We also measured phosphorylation of ERK2 in the medial prefrontal cortex (mPFC) and the dorsal hippocampus following fear conditioning or extinction in 6- and 15-week-old mice. We found that 10- and 15-week-old mice showed stronger fear memory and more resistance to fear extinction than 6-week-old mice. Moreover, 15-week-old mice showed lower ERK2 phosphorylation levels following fear extinction in the mPFC than those 6 weeks old. Our results suggest that female mice acquire strong fear memory and resistance to fear extinction throughout adulthood, which may be related to alteration in ERK2 activation in the mPFC.
诸如创伤后应激障碍等与恐惧相关的疾病的发病从青春期到成年期会增强。然而，这种易感性背后的生物学机制仍不清楚。因此，我们研究了4周、6周、8周、10周和15周龄雌性小鼠的情境恐惧记忆和消退情况。我们还测量了6周和15周龄小鼠在恐惧条件反射或消退后内侧前额叶皮质（mPFC）和背侧海马体中ERK2的磷酸化水平。我们发现，10周和15周龄的小鼠比6周龄的小鼠表现出更强的恐惧记忆和对恐惧消退的更强抵抗力。此外，15周龄小鼠在mPFC中恐惧消退后ERK2磷酸化水平低于6周龄小鼠。我们的结果表明，雌性小鼠在整个成年期都会获得强烈的恐惧记忆和对恐惧消退的抵抗力，这可能与mPFC中ERK2激活的改变有关。
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