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连续两次基于微管的上皮缝合事件介导了粪蝇的背侧闭合。

Two consecutive microtubule-based epithelial seaming events mediate dorsal closure in the scuttle fly .

机构信息

Cell and Developmental Biology Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.

Universitat Pompeu Fabra, Barcelona, Spain.

出版信息

Elife. 2018 Mar 14;7:e33807. doi: 10.7554/eLife.33807.

DOI:10.7554/eLife.33807
PMID:29537962
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5851697/
Abstract

Evolution of morphogenesis is generally associated with changes in genetic regulation. Here, we report evidence indicating that dorsal closure, a conserved morphogenetic process in dipterans, evolved as the consequence of rearrangements in epithelial organization rather than signaling regulation. In , dorsal closure consists of a two-tissue system where the contraction of extraembryonic amnioserosa and a JNK/Dpp-dependent epidermal actomyosin cable result in microtubule-dependent seaming of the epidermis. We find that dorsal closure in a three-tissue system comprising serosa, amnion and epidermis, differs in morphogenetic rearrangements despite conservation of JNK/Dpp signaling. In addition to an actomyosin cable, dorsal closure is driven by the rupture and contraction of the serosa and the consecutive microtubule-dependent seaming of amnion and epidermis. Our study indicates that the evolutionary transition to a reduced system of dorsal closure involves simplification of the seaming process without changing the signaling pathways of closure progression.

摘要

形态发生的进化通常与基因调控的变化有关。在这里，我们报告了一些证据，表明在双翅目昆虫中保守的背侧闭合形态发生过程是由于上皮组织的重新排列而不是信号调节的结果而进化的。在 中，背侧闭合由两个组织系统组成，其中胚外羊膜的收缩和 JNK/Dpp 依赖性表皮肌动球蛋白缆索导致微管依赖性表皮缝合。我们发现，尽管 JNK/Dpp 信号保持不变，但在 中，由浆膜、羊膜和表皮组成的三个组织系统的背侧闭合在形态发生的重新排列上存在差异。除了肌动球蛋白缆索之外， 背侧闭合还由浆膜的破裂和收缩以及随后的微管依赖性羊膜和表皮缝合驱动。我们的研究表明，向简化的背侧闭合系统的进化转变涉及到缝合过程的简化，而不改变闭合进展的信号通路。

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本文引用的文献

1
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Rouxs Arch Dev Biol. 1994 May;203(6):298-303. doi: 10.1007/BF00457800.
2
Morphogenetic functions of extraembryonic membranes in insects.昆虫胚胎外膜的形态发生功能。
Curr Opin Insect Sci. 2016 Feb;13:86-92. doi: 10.1016/j.cois.2016.01.009. Epub 2016 Feb 11.
3
Patterned Contractile Forces Promote Epidermal Spreading and Regulate Segment Positioning during Drosophila Head Involution.
模式化收缩力促进果蝇头部内卷过程中的表皮扩展并调节节段定位。
Curr Biol. 2016 Jul 25;26(14):1895-901. doi: 10.1016/j.cub.2016.05.027. Epub 2016 Jul 7.
4
Microtubule-dependent balanced cell contraction and luminal-matrix modification accelerate epithelial tube fusion.微管依赖的平衡细胞收缩和管腔基质修饰加速上皮管融合。
Nat Commun. 2016 Apr 12;7:11141. doi: 10.1038/ncomms11141.
5
The beetle amnion and serosa functionally interact as apposed epithelia.甲虫的羊膜和浆膜作为相对的上皮组织在功能上相互作用。
Elife. 2016 Jan 29;5:e13834. doi: 10.7554/eLife.13834.
6
Embryo-scale tissue mechanics during Drosophila gastrulation movements.果蝇原肠胚形成运动期间的胚胎尺度组织力学
Nat Commun. 2015 Oct 26;6:8677. doi: 10.1038/ncomms9677.
7
Evolution of epithelial morphogenesis: phenotypic integration across multiple levels of biological organization.上皮形态发生的演变：跨多个生物组织层次的表型整合。
Front Genet. 2015 Sep 29;6:303. doi: 10.3389/fgene.2015.00303. eCollection 2015.
8
Decrease in Cell Volume Generates Contractile Forces Driving Dorsal Closure.细胞体积减小产生收缩力驱动背侧闭合。
Dev Cell. 2015 Jun 8;33(5):611-21. doi: 10.1016/j.devcel.2015.03.016. Epub 2015 May 14.
9
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Sequential contraction and exchange of apical junctions drives zippering and neural tube closure in a simple chordate.顶端连接的连续收缩和交换驱动简单脊索动物的套索和神经管闭合。
Dev Cell. 2015 Jan 26;32(2):241-55. doi: 10.1016/j.devcel.2014.12.017.