Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea.
Chem Commun (Camb). 2018 Jun 19;54(50):6804-6807. doi: 10.1039/C8CC00574E.
A chiral aluminum solvating agent (CASA) was demonstrated to be a general and efficient reagent for 1H NMR chiral analysis of alcohols. The sodium salt of the CASA (CASA-Na) showed a complete baseline peak separation of the hydroxyl group for various chiral alcohols including primary, secondary, and tertiary alcohols with alkyl and aryl substituents in CD3CN. Due to the weak intermolecular interaction, 1H NMR measurement at low temperature (-40 to 10 °C) was required.
手性铝溶剂（CASA）被证明是一种用于醇的 1H NMR 手性分析的通用且高效的试剂。CASA 的钠盐（CASA-Na）在 CD3CN 中对各种手性醇（包括伯、仲和叔醇，以及具有烷基和芳基取代基的醇）的羟基表现出完全的基线峰分离。由于分子间相互作用较弱，需要在低温（-40 至 10°C）下进行 1H NMR 测量。
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