J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA.
J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA; Neuroscience Department and McKnight Brain Institute, University of Florida, Gainesville, FL 32611, USA.
Brain Behav Immun. 2018 May;70:3-4. doi: 10.1016/j.bbi.2018.03.017. Epub 2018 Mar 13.
A large proportion of Gulf War Veterans suffer from Gulf War Illness (GWI) - a devastating chronic disorder characterized by heterogeneous fatigue, pain and neuropsychological symptoms. In their recent Brain, Behavior and Immunity publication entitled "Curcumin Treatment Leads to Better Cognitive and Mood Function in a Model of Gulf War Illness with Enhanced Neurogenesis, and Alleviation of Inflammation and Mitochondrial Dysfunction in the Hippocampus", Kodali and colleagues (2018) report that the polyphenol curcumin improves cognition and mood in a rat model of GWI, potentially by increasing the expression of antioxidant genes and by reversing the effects of chronic combined acetylcholinesterase inhibitor exposure on neuroinflammation, mitochondrial respiration and hippocampal neurogenesis. This preclinical work is encouraging for our veterans who suffer chronically from GWI as well as for developing strategies to protect our troops during future deployments in similar environments.
很大一部分海湾战争老兵患有海湾战争综合征（GWI）——一种以异质性疲劳、疼痛和神经心理学症状为特征的毁灭性慢性疾病。在他们最近发表在《大脑、行为和免疫》杂志上的题为“姜黄素治疗可改善海湾战争综合征模型中的认知和情绪功能，增强海马神经发生，并减轻炎症和线粒体功能障碍”的研究中，Kodali 及其同事（2018 年）报告说，多酚姜黄素可改善 GWI 大鼠模型的认知和情绪，这可能是通过增加抗氧化基因的表达，以及逆转慢性联合乙酰胆碱酯酶抑制剂暴露对神经炎症、线粒体呼吸和海马神经发生的影响。这项临床前研究为我们那些长期患有 GWI 的退伍军人以及制定未来在类似环境中保护我们部队的策略提供了希望。
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