韩国膝关节骨关节炎患者的治疗模式。
Treatment patterns of knee osteoarthritis patients in Korea.
机构信息
Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea.
Department of Statistics, Kyungpook National University, Daegu, Korea.
出版信息
Korean J Intern Med. 2019 Sep;34(5):1145-1153. doi: 10.3904/kjim.2017.304. Epub 2018 Mar 21.
BACKGROUND/AIMS: To evaluate the treatment patterns of knee osteoarthritis (OA) patients in South Korea.
METHODS
Using the Korean nationwide claims database, all knee OA patients in Korea during 2014 were identified by the knee OA diagnostic code (M17) or any OA diagnostic code (M15 to M19) in combination with a procedure for a knee X-ray. Patterns of medications such as nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids (CSs), analgesics, and symptomatic slow acting drugs for OA (SYSADOA) were analyzed. Prevalence and characteristics of knee OA patients who received a CS intra-articular injection (IAI) were also evaluated.
RESULTS
We identified 2,016,516 knee OA patients whose age (mean ± standard deviation) was 63.2 ± 10.8 years. The number of patients with at least one use of NSAIDs, analgesics, CS, and SYSADOA were 82.5%, 32.2%, 8.6%, and 43.4%, respectively. The use of herbal SYSADOAs was 29.7%. For regular users (medication possession ratios ≥ 50%), the use of NSAIDs was substantially decreased (48.8%), while the use of SYSADOA (37.3%) and CS (6.7%) were not significantly changed. The number of CS IAI users among knee OA patients was 0.18%; they were slightly older (64.4 ± 10.9 vs. 63.2 ± 10.8, p < 0.01) and more skewed towards females (75.7% vs. 71.5%, p < 0.01) than patients who had not received CS IAI.
CONCLUSION
In Korea, the use of SYSADOA or CS in knee OA patients was relatively high. Further studies on the effectiveness and the safety of these treatment options for knee OA are needed.
背景/目的：评估韩国膝关节骨关节炎（OA）患者的治疗模式。
方法
使用韩国全国性索赔数据库，通过膝关节 OA 诊断代码（M17）或任何 OA 诊断代码（M15 至 M19）与膝关节 X 射线程序相结合，确定韩国所有膝关节 OA 患者。分析了非甾体抗炎药（NSAIDs）、皮质类固醇（CSs）、镇痛药和骨关节炎症状缓解药物（SYSADOA）等药物的使用模式。还评估了接受关节内注射皮质类固醇（IAI）的膝关节 OA 患者的流行率和特征。
结果
我们确定了 2016516 名膝关节 OA 患者，其年龄（平均值±标准差）为 63.2±10.8 岁。至少使用一次 NSAIDs、镇痛药、CS 和 SYSADOA 的患者比例分别为 82.5%、32.2%、8.6%和 43.4%。草药 SYSADOAs 的使用率为 29.7%。对于常规使用者（药物维持率≥50%），NSAIDs 的使用率显著降低（48.8%），而 SYSADOA（37.3%）和 CS（6.7%）的使用率无明显变化。膝关节 OA 患者中 CS IAI 的使用者比例为 0.18%；他们年龄稍大（64.4±10.9 岁比 63.2±10.8 岁，p<0.01），且更偏向女性（75.7%比 71.5%，p<0.01）。
结论
在韩国，膝关节 OA 患者使用 SYSADOA 或 CS 的比例相对较高。需要进一步研究这些治疗膝关节 OA 的选择的有效性和安全性。
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