Department of Surgery, University of California Irvine Medical Center, Orange, CA.
Institute for Clinical and Translational Science, University of California Irvine, Orange, CA.
J Am Coll Surg. 2018 Jun;226(6):1166-1174. doi: 10.1016/j.jamcollsurg.2018.02.013. Epub 2018 Mar 16.
Contemporary mortality after bariatric surgery is low and has been decreasing over the past 2 decades. Most studies have reported inpatient or 30-day mortality, which may not represent the true risk of bariatric surgery. The objective of this study was to examine 1-year mortality and factors predictive of 1-year mortality after contemporary laparoscopic bariatric surgery.
Using the 2008 to 2012 Bariatric Outcomes Longitudinal Database (BOLD), data from 158,606 operations were analyzed, including 128,349 (80.9%) laparoscopic Roux-en-Y gastric bypass (LRYGB) and 30,257 (19.1%) laparoscopic sleeve gastrectomy (LSG) operations. Multivariate logistic regression was used to determine independent risk factors associated with 1-year mortality for each type of procedure.
The 30-day and 1-year mortality rates for LRYGB were 0.13% and 0.23%, respectively, and for LSG were 0.06% and 0.11%, respectively. Risk factors for 1-year mortality included older age (LRYGB: adjusted odds ratio [AOR] 1.05 per year, p < 0.001; LSG: AOR 1.08 per year, p < 0.001); male sex (LRYGB: AOR 1.88, p < 0.001); higher BMI (LRYGB: AOR 1.04 per unit, p < 0.001; LSG: AOR 1.05 per unit, p = 0.009); and the presence of 30-day leak (LRYGB: AOR 25.4, p < 0.001; LSG: AOR 35.8, p < 0.001), 30-day pulmonary embolism (LRYGB: AOR 34.5, p < 0.001; LSG: AOR 252, p < 0.001), and 30-day hemorrhage (LRYGB: AOR 2.34, p = 0.001).
Contemporary 1-year mortality after laparoscopic bariatric surgery is much lower than previously reported, at <0.25%. It is important to continually refine techniques and perioperative management in order to minimize leaks, hemorrhage, and pulmonary embolus after bariatric surgery because these complications contribute to a higher risk of mortality.
当代减重手术后的死亡率较低,并且在过去 20 年中一直在下降。大多数研究报告了住院或 30 天死亡率,这可能不能代表减重手术的真实风险。本研究的目的是检查腹腔镜减重手术后 1 年的死亡率以及预测 1 年死亡率的因素。
使用 2008 年至 2012 年减重手术结果纵向数据库(BOLD),分析了 158606 例手术的数据,其中包括 128349 例(80.9%)腹腔镜 Roux-en-Y 胃旁路术(LRYGB)和 30257 例(19.1%)腹腔镜袖状胃切除术(LSG)。采用多变量逻辑回归确定每种手术方式与 1 年死亡率相关的独立危险因素。
LRYGB 的 30 天和 1 年死亡率分别为 0.13%和 0.23%,LSG 分别为 0.06%和 0.11%。1 年死亡率的危险因素包括年龄较大(LRYGB:调整后的优势比[OR]每年增加 1.05,p<0.001;LSG:每年增加 1.08,p<0.001);男性(LRYGB:OR 1.88,p<0.001);较高的 BMI(LRYGB:OR 每单位增加 1.04,p<0.001;LSG:OR 每单位增加 1.05,p=0.009);以及 30 天漏(LRYGB:OR 25.4,p<0.001;LSG:OR 35.8,p<0.001),30 天肺栓塞(LRYGB:OR 34.5,p<0.001;LSG:OR 252,p<0.001)和 30 天出血(LRYGB:OR 2.34,p=0.001)。
腹腔镜减重手术后 1 年的当代死亡率远低于以前报告的<0.25%。不断完善技术和围手术期管理非常重要,以便最大限度地减少减重手术后的漏、出血和肺栓塞,因为这些并发症会导致更高的死亡率。