Tian Sai-Sai, Yang Jian, Zhao Jing, Zhang Wei-Dong
College of Pharmacy, the Second Military Medical University, Shanghai 200433， China.
Institute of Interdisciplinary Complex Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203， China.
Zhongguo Zhong Yao Za Zhi. 2018 Jan;43(2):274-280. doi: 10.19540/j.cnki.cjcmm.20171027.018.
With the completion of the human genome project, people have gradually recognized that the functions of the biological system are fulfilled through network-type interaction between genes, proteins and small molecules, while complex diseases are caused by the imbalance of biological processes due to a number of gene expression disorders. These have contributed to the rise of the concept of the "multi-target" drug discovery. Treatment and diagnosis of traditional Chinese medicine are based on holism and syndrome differentiation. At the molecular level, traditional Chinese medicine is characterized by multi-component and multi-target prescriptions, which is expected to provide a reference for the development of multi-target drugs. This paper reviews the application of network biology in traditional Chinese medicine in six aspects, in expectation to provide a reference to the modernized study of traditional Chinese medicine.
随着人类基因组计划的完成，人们逐渐认识到生物系统的功能是通过基因、蛋白质和小分子之间的网络型相互作用来实现的，而复杂疾病是由多种基因表达紊乱导致的生物过程失衡所引起的。这些促使了“多靶点”药物研发概念的兴起。中医的治疗和诊断基于整体观和辨证论治。在分子层面，中药具有多成分、多靶点方剂的特点，有望为多靶点药物的研发提供参考。本文从六个方面综述了网络生物学在中医中的应用，以期为中医现代化研究提供参考。
