Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Division of Hematology, Brigham and Women's Hospital, Boston, MA, USA.
Blood Rev. 2018 Sep;32(5):361-367. doi: 10.1016/j.blre.2018.03.001. Epub 2018 Mar 5.
Pancytopenia is a relatively common phenomenon encountered in clinical practice. The evaluation of a patient with pancytopenia requires a comprehensive approach and identifying the underlying cause can be challenging given the wide range of etiologies including drugs, autoimmune conditions, malignancies, infections, hemophagocytosis, and inheritable conditions. Recent advances in molecular hematology which include genomic profiling and next-generation sequencing have helped gain major insights into various hematological conditions and can guide diagnosing specific diseases in a shorter time at lower costs. However the approach to manage patients with pancytopenia in the current era of genomics is not well defined in the literature and is widely variable in practice. Herein, we conducted a systematic review to help devise an algorithm and management approach for pancytopenia, which serves as a general consultative approach.
全血细胞减少是临床实践中较为常见的现象。评估全血细胞减少患者需要综合的方法，由于病因广泛，包括药物、自身免疫性疾病、恶性肿瘤、感染、噬血细胞现象和遗传性疾病，确定其根本原因具有挑战性。分子血液学的最新进展，包括基因组分析和下一代测序，帮助我们深入了解各种血液疾病，并能够以更低的成本在更短的时间内指导诊断特定疾病。然而，在基因组学时代，目前文献中并没有很好地定义管理全血细胞减少患者的方法，在实践中差异很大。在此，我们进行了一项系统评价，以帮助制定全血细胞减少症的算法和管理方法，作为一种通用的咨询方法。
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