Department of Gastrointestinal Surgery, The First People's Hospital of Zunyi, Zunyi Medical University, Zunyi, Guizhou, People's Republic of China.
Quality Control Department, The First People's Hospital of Zunyi, Zunyi Medical University, Zunyi, Guizhou, People's Republic of China.
Int J Surg. 2018 May;53:24-31. doi: 10.1016/j.ijsu.2018.03.027. Epub 2018 Mar 16.
Numbers of studies have demonstrated that estrogen receptor α and estrogen receptor β have been involved in development of gastric cancer. Hence, we analyzed studies and The Cancer Genome Atlas (TCGA) data of ERs expression and perform this meta-analysis to access the association between ERα or ER β and the clinicopathological characteristics, overall survival time, in GC.
A literature search was performed in PubMed, Cochrane Library, Web of Science, EMBASE database, and Chinese CNKI. Data on the relationship between ERα or ERβ expression and clinicopathological features were extracted. A TCGA dataset including information of the ERs expression and clinical data of GC patients was analyzed. Pooled odds ratios (ORs) and hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated.
ERα was not associated with cancer risk, lymph node metastasis, infiltration degree, gender, and TNM stage. However, ERβ was negatively associated with lymph node metastasis. ERα expression may be associated with poor prognosis in GC patients.
Estrogen receptors may be related to the progression and deterioration of gastric cancer. However, further high-quality studies are needed to provide more reliable evidence.
许多研究表明，雌激素受体α（ERα）和雌激素受体β（ERβ）参与了胃癌的发生发展。因此，我们分析了 ERs 表达的研究和癌症基因组图谱（TCGA）数据，并进行了这项荟萃分析，以评估 ERα 或 ERβ 与 GC 临床病理特征和总生存时间之间的相关性。
我们在 PubMed、Cochrane 图书馆、Web of Science、EMBASE 数据库和中国知网（CNKI）中进行了文献检索，提取了 ERα 或 ERβ 表达与临床病理特征之间关系的数据。分析了包含 GC 患者 ERs 表达和临床数据的 TCGA 数据集。计算了合并的优势比（ORs）和风险比（HRs）及其 95%置信区间（CIs）。
ERα 与癌症风险、淋巴结转移、浸润程度、性别和 TNM 分期均无相关性。然而，ERβ 与淋巴结转移呈负相关。ERα 表达可能与 GC 患者的预后不良有关。
雌激素受体可能与胃癌的进展和恶化有关。然而，需要进一步的高质量研究提供更可靠的证据。
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