99mTc MDP SPECT-CT 引导下改良 Mirels 评分对骨骼转移风险骨折评估：一项初步研究。

99mTc MDP SPECT-CT-Based Modified Mirels Classification for Evaluation of Risk of Fracture in Skeletal Metastasis: A Pilot Study.

出版信息

Clin Nucl Med. 2018 Jun;43(6):e180-e183. doi: 10.1097/RLU.0000000000002057.

DOI:10.1097/RLU.0000000000002057

Abstract

Mirels' scoring system quantifies the risk of sustaining a pathologic fracture in osseous metastases of weight bearing long bones. Conventional Mirels' scoring is based on radiographs. Our pilot study proposes Tc MDP bone SPECT-CT based modified Mirels' scoring system and its comparison with conventional Mirels' scoring. Cortical lysis was noted in 8(24%) by SPECT-CT versus 2 (6.3%) on X-rays. Additional SPECT-CT parameters were; circumferential involvement [1/4 (31%), 1/2 (3%), 3/4 (37.5%), 4/4 (28%)] and extra-osseous soft tissue [3%]. Our pilot study suggests the potential role of SPECT-CT in predicting risk of fracture in osseous metastases.

摘要

Mirels 评分系统定量评估承重长骨骨转移中发生病理性骨折的风险。传统的 Mirels 评分基于 X 射线。我们的初步研究提出了基于 Tc-MDP 骨 SPECT-CT 的改良 Mirels 评分系统及其与传统 Mirels 评分的比较。SPECT-CT 显示 8 例（24%）存在皮质溶解，而 X 射线仅显示 2 例（6.3%）。SPECT-CT 的其他参数包括：环形受累[1/4（31%）、1/2（3%）、3/4（37.5%）、4/4（28%）]和骨外软组织[3%]。我们的初步研究表明，SPECT-CT 在预测骨转移中骨折风险方面具有潜在作用。